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(Radiology. 1999;213:825-830.)
© RSNA, 1999

Gastrointestinal Imaging

Size of Colorectal Liver Metastases at Abdominal CT: Comparison of Precontrast and Postcontrast Studies1

Levon N. Nazarian, MD, Jennifer H. Park, MD, Ethan J. Halpern, MD, Laurence Parker, PhD, Pamela T. Johnson, MD, Anna S. Lev-Toaff, MD and Richard J. Wechsler, MD

1 From the Department of Radiology, Thomas Jefferson University Hospital, 7th Fl, Main Bldg, 132 S 10th St, Philadelphia, PA 19107-5244. From the 1998 RSNA scientific assembly. Received December 17, 1998; revision requested February 18, 1999; revision received April 7; accepted June 17. Address reprint requests to L.N.N.

PURPOSE: To investigate whether measurements of hepatic metastases from colorectal carcinoma before contrast material administration are significantly different statistically from measurements after contrast material administration.

MATERIALS AND METHODS: Twenty-four patients with hepatic metastases from colorectal carcinoma underwent spiral computed tomography (CT) with 7-mm collimation. The liver was imaged before and in the portal-dominant phase after intravenous contrast material administration. For each scan, one to three discrete liver lesions were selected for measurement (n = 49). Three experienced radiologists performed independent measurements of the selected lesions on both pre- and postcontrast images at a computer workstation. A three-way analysis of variance (ANOVA) was performed: subjects by raters (the three independent radiologists) by pre- or postcontrast status. The dependent variable was the product of bidimensional measurements.

RESULTS: Sixty-seven percent (33 of 49) of the lesions were measured as larger on precontrast images; 33% (16 of 49), as smaller. There was high interrater reliability, with an intraclass correlation coefficient greater than 0.9. ANOVA showed significant subject, rater, and contrast material effects (P < .001) for the largest lesions in each liver. Contrast material status was a significant factor for all lesion sizes (P < .003).

CONCLUSION: On average, hepatic metastases from colorectal carcinoma are significantly smaller after contrast material administration.

Index terms: Colon, neoplasms, 75.321 • Computed tomography (CT), contrast enhancement, 761.12114 • Liver neoplasms, CT, 761.12111, 761.12114, 761.12115, 761.332 • Liver neoplasms, secondary, 761.331, 761.332




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