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(Radiology. 1999;213:871-879.)
© RSNA, 1999

Experimental Studies

Pulmonary Disorders: Ventilation-Perfusion MR Imaging with Animal Models1

Qun Chen, PhD, David L. Levin, MD, PhD, Ducksoo Kim, MD, Vivek David, MD, Michelle McNicholas, MD, Victoria Chen, Peter M. Jakob, PhD, Mark A. Griswold, BSc, James W. Goldfarb, MSc, Hiroto Hatabu, MD, PhD and Robert R. Edelman, MD

1 From the Dept of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, AN-241, Boston, MA 02215. From the 1998 RSNA scientific assembly. Received Aug 26, 1998; revision requested Oct 22; revision received Feb 18, 1999; accepted Jul 1. Q.C. supported by Scientist Development Grant from the American Heart Association and Genentech. R.R.E. supported in part by grant R01HL57437 from National Institutes of Health and the Lauterbur Award from the Society of Computed Body Tomography and Magnetic Resonance. M.M. supported in part by 1996 RSNA seed grant. Address reprint requests to Q.C. (e-mail: qchen@caregroup.harvard.edu).

PURPOSE: To demonstrate the capability of magnetic resonance (MR) imaging to assess alteration in regional pulmonary ventilation and perfusion with animal models of airway obstruction and pulmonary embolism.

MATERIALS AND METHODS: Airway obstruction was created by inflating a 5-F balloon catheter into a secondary bronchus. Pulmonary emboli were created by injecting thrombi into the inferior vena cava. Regional pulmonary ventilation was assessed with 100% oxygen as a T1 contrast agent. Regional pulmonary perfusion was assessed with a two-dimensional fast low-angle shot, or FLASH, sequence with short repetition and echo times after intravenous administration of gadopentetate dimeglumine.

RESULTS: Matched ventilation and perfusion abnormalities were identified in all animals with airway obstruction. MR perfusion defects without ventilation abnormalities were seen in all animals with pulmonary emboli.

CONCLUSION: Ventilation and perfusion MR imaging are able to provide regional pulmonary functional information with high spatial and temporal resolution. The ability of MR imaging to assess both the magnitude and regional distribution of pulmonary functional impairment could have an important effect on the evaluation of lung disease.

Index terms: Bronchi, stenosis or obstruction, 671.90 • Embolism, experimental studies, 60.72 • Gadolinium • Lung, MR, 60.121411, 60.121413, 60.12143 • Lung, perfusion • Lung, ventilation • Oxygen




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