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Genitourinary Imaging |
1 From the Departments of Diagnostic Imaging (D.B.S.) and Obstetrics and Gynecology (S.C.P.), Kaiser Permanente Medical Center, 280 W MacArthur Blvd, Oakland, CA 94611-5693, and Health Services Research, Berkeley, Calif (H.E.B.). Received December 23, 1998; revision requested February 19, 1999; revision received April 20; accepted July 29. Supported in part by Kaiser Permanente Medical Care Program–Northern California Innovation Project grant no. 930198. Address reprint requests to D.B.S. (e-mail: David.Spring@kp.org).
PURPOSE: To evaluate the influence of the contrast material used in hysterosalpingography (HSG) on subsequent reproductive success, independent of other therapeutic interventions.
MATERIALS AND METHODS: In a prospective, multisite, randomized trial, 666 women who had been infertile for more than 1 year and were scheduled to undergo HSG as part of their evaluation were assigned to one of three groups: those receiving water-soluble contrast material (WSCM) (n = 260), those receiving oil-soluble contrast material (OSCM) (n = 273), and those receiving both OSCM and WSCM (n = 133). Possible causes of infertility and therapeutic interventions were abstracted from the medical records. Data on conception within 1 year and the outcome of conception were ascertained from multiple sources.
RESULTS: Of 666 women, 204 (30.6%) had at least one pregnancy, and 136 (20.4%) had live births. The rates of live births were 20.4% (54 of 260) after HSG with WSCM, 19.4% (53 of 273) after HSG with OSCM, and 21.8% (29 of 133) after HSG with both WSCM and OSCM. Differences in reproductive outcome among contrast material groups were not statistically significant (
28 = 6.08, P = .64). Whatever the cause of infertility, the use of different contrast materials led to no significant differences in the rates of live births.
CONCLUSION: There is no evidence to suggest that the choice of contrast material affects the rate of term pregnancy.
Index terms: Abortion, 854.8252 • Contrast media, comparative studies • Contrast media, therapeutic effects • Pregnancy, 854.131 • Pregnancy, ectopic, 854.823 • Uterus, radiography, 854.1282
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