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(Radiology. 2000;214:341-348.)
© RSNA, 2000

Vascular and Interventional Radiology

Symptomatic Vertebral Hemangiomas: Treatment by Means of Direct Intralesional Injection of Ethanol1

John L. Doppman, MD, Edward H. Oldfield, MD and John D. Heiss, MD

1 From the Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center (J.L.D.) and the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (E.H.O., J.D.H.), National Institutes of Health, Bldg 10, Rm 1C660, 10 Center Dr, MSC 1182, Bethesda, MD 20892-1182. Received December 28, 1998; revision requested March 8, 1999; final revision received May 18; accepted May 27. Address reprint requests to J.L.D. (e-mail: jdoppman@nih.gov).

PURPOSE: To describe the technique and results of injecting ethanol directly into symptomatic vertebral hemangiomas.

MATERIALS AND METHODS: Eleven patients with paraplegia (n = 6) or radiculopathy (n = 5) due to vertebral hemangioma were treated by means of injecting ethanol (5–50 mL) directly into the lesion with computed tomographic (CT) guidance. CT angiograms were essential prior to treatment to identify functional vascular spaces of the hemangioma and direct needle placement.

RESULTS: All hemangiomas were obliterated completely at follow-up angiography and gadolinium-enhanced magnetic resonance imaging. Five of six patients with paraplegia recovered completely: One who was treated recently was walking with assistance. Four of five patients with radiculopathy improved. No immediate complications were associated with ethanol injection. The two patients who received the largest volumes of ethanol, 42 and 50 mL, developed pathologic fractures of the involved vertebrae 4 and 16 weeks after treatment.

CONCLUSION: Direct injection of ethanol into symptomatic vertebral hemangioma is an effective and safe treatment, provided the dose is less than 15 mL.

Index terms: Angioma, skeletal system, 30.3141 • Spinal cord, compression, 30.82 • Spine, angiography, 30.124 • Spine, CT, 30.12112, 30.12116 • Spine, interventional procedures, 30.126 • Spine, MR, 30.121411, 30.121412, 30.121415




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