HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Choi, B. I. Articles by Park, S. J. Search for Related Content PubMed PubMed Citation Articles by Choi, B. I. Articles by Park, S. J.

Vascularity of Hepatocellular Carcinoma: Assessment with Contrast-enhanced SecondHarmonic versus Conventional Power Doppler US¹

¹ From the Department of Radiology and the Institute of Radiation Medicine, Seoul National University Hospital, 28, Yongon-dong, Chongno-gu, Seoul 110-744, South Korea. Received February 4, 1999; revision requested April 2; revision received May 14; accepted June 2. Supported in part by a grant from the 1998 Highly Advanced National Projects on the Development of Biomedical Engineering and Technology in Korea. Address reprint requests to B.I.C.

PURPOSE: To compare contrast material–enhanced harmonic power Doppler ultrasonography (US) with conventional power Doppler US in depicting the vascularity of hepatocellular carcinoma (HCC).

MATERIALS AND METHODS: Twenty patients with nodular HCCs (2.6–13.2 cm in diameter; mean diameter, 4.8 cm) were prospectively examined with both conventional and harmonic power Doppler US. US was performed with a 2–4-MHz curved linear-array transducer according to a standard examination protocol (1,000-Hz pulse repetition frequency, medium wall filter, and power gain of 55%–84% for conventional power Doppler US; 700-Hz pulse repetition frequency, low wall filter, and power gain of 95%–98% for harmonic power Doppler US). Serial, dynamic scans were obtained before intravenous injection of the contrast agent (SH U 508A) and at 30, 60, 90, 120, 180, 240, and 300 seconds after injection with both techniques.

RESULTS: The number of intratumoral power Doppler US signals was similar with both techniques at 30–90 seconds after contrast agent injection; however, after 90 seconds, conventional power Doppler US depicted significantly more signals than did harmonic power Doppler US. Harmonic power Doppler US was superior to conventional power Doppler US in terms of power Doppler artifacts such as "blooming" or motion-related artifacts.

CONCLUSION: Although the effective enhancement duration is relatively short compared with that for conventional power Doppler US, contrast-enhanced harmonic power Doppler US can be effective in evaluating the vascularity of HCCs because of the advantage of fewer power Doppler artifacts.

Index terms: Liver neoplasms, blood supply, 761.323, 761.99, 95.32, 95.99 • Liver neoplasms, US, 761.12983, 761.12988 • Ultrasound (US), artifact, 761.93 • Ultrasound (US), comparative studies, 761.12983, 761.12988, 761.12989 • Ultrasound (US), contrast media, 761.12988 • Ultrasound (US), harmonic study, 761.12989 • Ultrasound (US), power Doppler studies, 761.12983

This article has been cited by other articles:

				K. Takayasu, Y. Muramatsu, Y. Mizuguchi, T. Okusaka, K. Shimada, T. Takayama, and M. Sakamoto CT Evaluation of the progression of hypoattenuating nodular lesions in virus-related chronic liver disease. Am. J. Roentgenol., August 1, 2006; 187(2): 454 - 463. [Abstract] [Full Text] [PDF]

				C. Hsu, C.-N. Chen, L.-T. Chen, C.-Y. Wu, F.-J. Hsieh, and A.-L. Cheng Effect of Thalidomide in Hepatocellular Carcinoma: Assessment with Power Doppler US and Analysis of Circulating Angiogenic Factors Radiology, May 1, 2005; 235(2): 509 - 516. [Abstract] [Full Text] [PDF]

				M. Morimoto, A. Nozawa, K. Numata, K. Shirato, K. Sugimori, A. Kokawa, N. Tomita, T. Saitou, Y. Nakatani, T. Imada, et al. Evaluation Using Contrast-Enhanced Harmonic Gray Scale Sonography After Radio Frequency Ablation of Small Hepatocellular Carcinoma: Sonographic-Histopathologic Correlation J. Ultrasound Med., March 1, 2005; 24(3): 273 - 283. [Abstract] [Full Text] [PDF]

				H. Ding, W.-P. Wang, B.-J. Huang, R.-X. Wei, N.-A. He, Q. Qi, and C.-L. Li Imaging of Focal Liver Lesions: Low-Mechanical-Index Real-time Ultrasonography With SonoVue J. Ultrasound Med., March 1, 2005; 24(3): 285 - 297. [Abstract] [Full Text] [PDF]

				M. J. Kim, H. K. Lim, S. H. Kim, D. Choi, W. J. Lee, S. J. Lee, and J. H. Lim Evaluation of Hepatic Focal Nodular Hyperplasia With Contrast-Enhanced Gray Scale Harmonic Sonography: Initial Experience J. Ultrasound Med., February 1, 2004; 23(2): 297 - 305. [Abstract] [Full Text] [PDF]

				K. W. Kim, B. I. Choi, S. H. Park, H.-C. Kim, M. W. Lee, S. H. Kim, K. H. Lee, C. H. Park, J. S. Kim, H.-J. Won, et al. Hepatocellular Carcinoma: Assessment of Vascularity With Single-Level Dynamic Ultrasonography During the Arterial Phase J. Ultrasound Med., September 1, 2003; 22(9): 887 - 896. [Abstract] [Full Text] [PDF]

				M. Morimoto, K. Shirato, K. Sugimori, A. Kokawa, N. Tomita, T. Saito, T. Imada, N. Tanaka, A. Nozawa, K. Numata, et al. Contrast-Enhanced Harmonic Gray-Scale Sonographic-Histologic Correlation of the Therapeutic Effects of Transcatheter Arterial Chemoembolization in Patients with Hepatocellular Carcinoma Am. J. Roentgenol., July 1, 2003; 181(1): 65 - 69. [Abstract] [Full Text] [PDF]

				W. T. Yang, G. M. K. Tse, P. K. W. Lam, C. Metreweli, and J. Chang Correlation Between Color Power Doppler Sonographic Measurement of Breast Tumor Vasculature and Immunohistochemical Analysis of Microvessel Density for the Quantitation of Angiogenesis J. Ultrasound Med., November 1, 2002; 21(11): 1227 - 1235. [Abstract] [Full Text] [PDF]

				K. Takayasu, T. Maeda, and R. Iwata Sensitivity of Superselective Arteriography for Small Hepatocellular Carcinoma Compared with Proximal Arteriography and Computed Tomography During Superselective Arteriography Jpn. J. Clin. Oncol., June 1, 2002; 32(6): 191 - 195. [Abstract] [Full Text] [PDF]

				J. H. Kim, T. K. Kim, B. S. Kim, H. W. Eun, P. N. Kim, M.-G. Lee, and H. K. Ha Enhancement of Hepatic Hemangiomas With Levovist on Coded Harmonic Angiographic Ultrasonography J. Ultrasound Med., February 1, 2002; 21(2): 141 - 148. [Abstract] [Full Text] [PDF]

				B. I. Choi, A. Y. Kim, J. Y. Lee, K. W. Kim, K. H. Lee, T. K. Kim, and J. K. Han Hepatocellular Carcinoma: Contrast Enhancement With Levovist J. Ultrasound Med., January 1, 2002; 21(1): 77 - 84. [Abstract] [Full Text] [PDF]

				D. Cioni, R. Lencioni, S. Rossi, F. Garbagnati, F. Donati, L. Crocetti, and C. Bartolozzi Radiofrequency Thermal Ablation of Hepatocellular Carcinoma: Using Contrast-Enhanced Harmonic Power Doppler Sonography to Assess Treatment Outcome Am. J. Roentgenol., October 1, 2001; 177(4): 783 - 788. [Abstract] [Full Text] [PDF]

				K. Numata, K. Tanaka, T. Kiba, S. Saito, T. Isozaki, K. Hara, M. Morimoto, H. Sekihara, H. Yonezawa, and T. Kubota Using Contrast-Enhanced Sonography to Assess the Effectiveness of Transcatheter Arterial Embolization for Hepatocellular Carcinoma Am. J. Roentgenol., May 1, 2001; 176(5): 1199 - 1205. [Abstract] [Full Text] [PDF]

				H. Ding, M. Kudo, H. Onda, Y. Suetomi, Y. Minami, and K. Maekawa Contrast-Enhanced Subtraction Harmonic Sonography for Evaluating Treatment Response in Patients with Hepatocellular Carcinoma Am. J. Roentgenol., March 1, 2001; 176(3): 661 - 666. [Abstract] [Full Text] [PDF]