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Parathyroid Glands: Combination of ^99mTc MIBI Scintigraphy and US for Demonstration of Parathyroid Glands and Nodules¹

¹ From the Endocrine (M.L.D.F., C.B., M.S., M.L.B.), Radiology (S.C., A.T.), Surgery (D.B., P.C., F.T.), and Nuclear Medicine Units (G.B., L.V.) of the Department of Clinical Physiopathology, and the Pathologic Anatomy Unit (A.A.), University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. Received January 14, 1998; revision requested April 2; final revision received April 28, 1999; accepted June 1. Supported in part the Associazione Italiana per la Ricerca sul Cancro (AIRC). Address reprint requests to M.L.B. (e-mail: m.brandi@dfc.unifi.it).

PURPOSE: To determine the appropriate choice of imaging techniques for localization of nodular lesions of parathyroid glands.

MATERIALS AND METHODS: First, computed tomographic (CT), magnetic resonance (MR), ultrasonographic (US), and technetium 99m methoxyisobutyl-isonitrile (MIBI) scintigraphic images in 49 patients with primary hyperparathyroidism were retrospectively evaluated. A single-blind, prospective study that included 16 patients with primary hyperparathyroidism was then conducted. MR, US, scintigraphic, and color Doppler US images of the neck were obtained and analyzed.

RESULTS: In the retrospective study, CT, MR imaging, and US had low sensitivity (13%, 17%, and 27%, respectively) and specificity (39%, 65%, and 65%, respectively). Scintigraphy had 57% sensitivity and 85% specificity. In the prospective study, the use of latest-generation MR and US equipment and the participation of experienced operators led to improved sensitivity and specificity for these techniques. The combination of US and scintigraphy resulted in improved sensitivity (96%), specificity (83%), and positive and negative predictive values (88% and 94%, respectively), relative to the results obtained with either method alone. Doppler US was of little help in the setting of small glands.

CONCLUSIONS:

The combination of ^99mTc MIBI scintigraphy and US performed by well-trained operators with up-to-date instruments appeared to be the best diagnostic tool for the preoperative diagnosis of parathyroid disease.

Index terms: Parathyroid, CT, 274.1211 • Parathyroid, hyperparathyroidism, 274.531 • Parathyroid, MR, 274.121411, 274.12143 • Parathyroid, neoplasms, 274.363 • Parathyroid, radionuclide studies, 274.12175 • Parathyroid, US, 274.12981, 274.12983

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