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(Radiology. 2000;214:787-794.)
© RSNA, 2000

Experimental Studies

Comparison of Two Blood Pool Contrast Agents for 0.5-T MR Angiography: Experimental Study in Rabbits1

Sharon E. Clarke, BSc, Hanns-Joachim Weinmann, PhD, Erbin Dai, MD, Alexandra R. Lucas, MSc, MD and Brian K. Rutt, PhD

1 From the Robarts Research Institute, Imaging Research Laboratories, PO Box 5015, 100 Perth Dr, London, Ontario, Canada N6A 5K8 (S.E.C., E.D., A.R.L., B.K.R.); the Department of Medical Biophysics, University of Western Ontario, London, Canada (S.E.C., B.K.R.); and the Schering Contrast Media Research Laboratories, Berlin, Germany (H.J.W.). Received April 2, 1999; revision requested May 21; revision received June 18; accepted August 10. Supported in part by grants from Schering Contrast Media Research Laboratories and the Medical Research Council of Canada (no. MT-14315). Address reprint requests to B.K.R. (brutt@irus.rri.on.ca).

PURPOSE: To evaluate two experimental blood pool agents for potential use in equilibrium phase abdominal magnetic resonance (MR) angiography.

MATERIALS AND METHODS: MR imaging at 0.5 T was performed in 37 rabbits before and after intravenous injection of a gadolinium-based blood pool contrast agent (SH L 643 A), superparamagnetic iron oxide blood pool agent (SH U 555 C), or gadopentetate dimeglumine. T1-weighted fast spoiled gradient-echo images from the renal arteries to below the iliac bifurcation were obtained. The aorta-to-tissue signal difference–to-noise ratio (SDNR) was measured over time.

RESULTS: Both blood pool agents yielded excellent demonstration of the rabbit abdominal aorta. At a dose of 0.1 mmol/kg, both provided a statistically significant increase in aorta-to-tissue SDNR in comparison with that achieved with gadopentetate dimeglumine (200% increase for SH L 643 A, 95% increase for SH U 555 C; P < .05). A 0.1 mmol/kg dose of SH L 643 A provided a 24% increase in SDNR relative to the increase with a 0.37 mmol/kg dose of gadopentetate dimeglumine. Time-dependent enhancement properties of the blood pool agents differed due to differences in elimination method.

CONCLUSION: Both blood pool agents were found to be promising contrast agents for 0.5-T MR angiography; however, their clinical applicability warrants further investigation. The gadolinium-based agent had several advantages over the iron oxide compound, including less T2* dephasing, lack of susceptibility artifacts, and fast renal elimination.

Index terms: Contrast media, comparative studies • Contrast media, experimental studies • Gadolinium • Iron • Magnetic resonance (MR), contrast media, 981.12943 • Magnetic resonance (MR), vascular studies, 981.129412, 981.12942, 981.12943




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