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Human Breast Cancer Specimens: Diffraction-enhanced Imaging with Histologic Correlation-Improved Conspicuity of Lesion Detail Compared with Digital Radiography¹

¹ From the Departments of Radiology (E.D.P., R.E.J., D.B.W.) and Pathology (M.V.I., C.A.L.) and the UNC-Lineberger Comprehensive Cancer Center (E.D.P.), University of North Carolina School of Medicine, Manning Dr, Chapel Hill, NC 27599-7510; the Department of Physics and Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago (D.C.); the Nuffield Department of Pathology and Bacteriology, University of Oxford, United Kingdom (J.G.); the Department of Physics, North Carolina State University, Raleigh (D.E.S., M.Z.K.); the Brookhaven National Laboratory, Upton, NY (Z.Z.); and the European Synchrotron Radiation Facility, Grenoble, France (W.C.T.). Received February 1, 1999; revision requested March 31; final revision received June 25; accepted July 20. Supported in part by U.S. Army grant DAMD 17-96-1-6143, by the National Synchrotron Light Source at Brookhaven National Laboratory under U.S. Department of Energy contract DE-AC 02-76CH00016, and by the State of Illinois Higher Education Cooperative Agreement. Address reprint requests to E.D.P. (e-mail: etpisano@med.unc.edu).

Seven breast cancer specimens were examined with diffraction-enhanced imaging at 18 keV with a silicon crystal with use of the silicon 333 reflection in Bragg mode. Images were compared with digital radiographs of the specimen, and regions of increased detail were identified. Six of the seven cases (86%) showed enhanced visibility of surface spiculation that correlated with histopathologic information, including extension of tumor into surrounding tissue.

Index terms: Breast radiography, technology, 00.119 • Synchrotron

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