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(Radiology. 2000;214:912-917.)
© RSNA, 2000


Technical Developments

Vascular Permeability: Quantitative Measurement with Double-Echo Dynamic MR Imaging-Theory and Clinical Application1

Hidemasa Uematsu, MD, Masayuki Maeda, MD, Norihiro Sadato, MD, Tsuyoshi Matsuda, RT, Yoshiyuki Ishimori, RT, Yoshio Koshimoto, MD, Hiroki Yamada, MD, Hirohiko Kimura, MD, Yasutaka Kawamura, MD, Tetsuya Matsuda, MD, Nobushige Hayashi, MD, Yoshiharu Yonekura, MD and Yasushi Ishii, MD

1 From the Department of Radiology (H.U., M.M., Y. Ishimori, Y. Koshimoto, H.Y., H.K., Y. Kawamura, N.H., Y. Ishii) and the Biomedical Imaging Research Center (N.S., Y.Y.), Fukui Medical University, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui, 910-1193 Japan; GE-Yokogawa Medical Systems, Tokyo, Japan (Tsuyoshi M.); the Department of Medical Informatics, Kyoto University Hospital, Kyoto, Japan (Tetsuya M.); and the Department of Cerebral Research, National Institute for Physiological Sciences, Okazaki, Japan (N.S.). Received July 31, 1998; revision requested September 11; final revision received June 28, 1999; accepted August 12. Supported in part by research grant JSPS-RFTF97L00203 from the Japan Society for the Promotion of Science and by an international exchange grant from the Japan Society of Magnetic Resonance in Medicine. Address reprint requests to H.U. (e-mail: uematsu@fmsrsa.fukui-med.ac.jp).

Double-echo dynamic magnetic resonance (MR) imaging was used to evaluate both vascularity and permeability of tissues simultaneously. Vascularity was evaluated on the basis of the T2*-shortening effect due to the intravascular fraction of the contrast agent and permeability on the basis of the T1-shortening effect due to the extravascular fraction. Meningioma was characterized on the basis of higher vascularity and neurinoma on the basis of higher permeability. The proposed method enables better tissue characterization.

Index terms: Brain, MR, 13.121411, 13.121412 • Brain, neoplasms, 13.3641, 13.366 • Magnetic resonance (MR), diffusion study, 13.12144 • Magnetic resonance (MR), perfusion study, 13.12144 • Magnetic resonance (MR), tissue characterization, 13.121411, 13.121412 • Meninges, MR, 139.121411, 139.121412 • Meninges, neoplasms, 139.366




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