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Experimental Studies |
1 From the Departments of Obstetrics and Gynecology (N.M., T. Kubota, T.A.), Neuropathology (T. Kuroiwa), Neurology (F.Y.Z.), Neurosurgery (T.N., H.A.), and Radiology (I.Y.), Faculty of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519 Japan. Received February 26, 1999; revision requested May 6; revision received August 9; accepted August 18. Address reprint requests to N.M. (e-mail: n.miyasaka.gyne@med.tmd.ac.jp).
PURPOSE: To compare the apparent diffusion coefficients (ADCs) and histologic changes in young rats subjected to cerebral ischemic hypoxia (IH).
MATERIALS AND METHODS: Fifteen 3-week-old rats were subjected to a 30-minute IH insult (unilateral common carotid arterial ligation and exposure to 8% oxygen) and were examined at diffusion-weighted magnetic resonance imaging and light and electron microscopy on cessation of the insult (n = 5), 60 minutes after resuscitation (n = 5), or 48 hours after resuscitation (n = 5). Twelve control rats either underwent unilateral common carotid arterial ligation or were subjected to hypoxia.
RESULTS: The experimental rats showed primary ADC reduction during the insult, transient ADC recovery after resuscitation, and secondary ADC reduction 48 hours after the insult. Histologic examination revealed dendritic swelling and mild swelling of the perivascular astrocytic end-feet during the primary ADC reduction phase, dark neurons and pronounced swelling of the perivascular astrocytic end-feet during the transient ADC recovery phase, and severely retracted dark neurons and extensive swelling of the astrocytic end-feet during the secondary ADC reduction phase.
CONCLUSION: Transient ADC normalization after cerebral IH does not necessarily mean that histologic normalization has occurred. The transient ADC recovery phase appeared to have limited potential for neuronal salvage.
Index terms: Animals • Brain, ischemia, 10.781 • Brain, MR, 10.121411, 10.12144, 10.781 • Magnetic resonance (MR), comparative studies • Magnetic resonance (MR), diffusion study, 10.121411, 10.12144 • Magnetic resonance (MR), experimental studies
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