Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borges-Neto, S.
Right arrow Articles by Coleman, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borges-Neto, S.
Right arrow Articles by Coleman, R. E.
(Radiology. 2000;215:529-533.)
© RSNA, 2000

Nuclear Medicine

Poststress Measurements of Left Ventricular Function with Gated Perfusion SPECT: Comparison with Resting Measurements by Using a Same-Day Perfusion-Function Protocol1

Salvador Borges-Neto, MD, Aamir Javaid, MD, Linda K. Shaw, BS, David F. Kong, MD, Michael W. Hanson, MD, Robert A. Pagnanelli, CNMT, Gregory Ravizzini, MD and R. E. Coleman, MD

1 From the Departments of Radiology—Nuclear Medicine (S.B.N., M.W.H., R.A.P., G.R., R.E.C.) and Medicine—Cardiology (S.B.N., A.J., L.K.S., D.F.K., M.W.H.), Duke University Medical Center and Health Systems, Duke North Rm 1410, PO Box 3949, Durham, NC 27710. Received May 3, 1999; revision requested June 16; final revision received October 18; accepted October 20. Address correspondence to S.B.N. (e-mail: borge001@mc.duke.edu.)

PURPOSE: To investigate the relationship between the development of ischemia during stress testing and the changes in left ventricular ejection fraction (LVEF) measurements obtained after stress and at rest with a same-day perfusion-function imaging protocol.

MATERIALS AND METHODS: One hundred twenty-six patients underwent a same-day rest-stress (61%) or stress-rest (39%) protocol and gated single photon emission computed tomography (SPECT). Perfusion analysis was performed with a 12-segment model. Defects were scored (0 = no defect, 1 = mild defect, 2 = moderate defect, and 3 = severe defect); differences between the summed stress and resting scores of greater than three indicated substantial ischemia.

RESULTS: Resting and poststress LVEFs correlated significantly (r = 0.97, P < .001); however, patients with and patients without ischemia had significant differences in poststress versus resting LVEFs (-4.0 vs 1.0, respectively; P < .01). In patients with ischemia versus patients without ischemia, subgroup analysis stress-rest (-2.5 vs 1.0, P = .047) and rest-stress (-4.0 vs 1.0, P = .006) protocols yielded similar results.

CONCLUSION: In patients with clinically important stress-induced perfusion abnormalities, the LVEF after stress was significantly lower than the LVEF at rest with same-day rest-stress and stress-rest imaging protocols. In the clinical setting, poststress LVEFs may be lower than true resting measurements, particularly in patients with moderate to severe stress-induced ischemia.

Index terms: Heart, ejection fraction • Heart, function • Myocardium, ischemia, 511.1939 • Myocardium, radionuclide studies, 511.1939, 511.12171 • Myocardium, SPECT, 511.1939, 511.12162 • Receiver operating characteristic (ROC) curve • Single photon emission computed tomography (SPECT), 511.12162




This article has been cited by other articles:


Home page
 J. Nucl. Med. Technol.Home page
J. M. Wheat and G. M. Currie
Rest Versus Stress Ejection Fraction on Gated Myocardial Perfusion SPECT
J. Nucl. Med. Technol., December 1, 2005; 33(4): 218 - 223.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
A. Manrique, A. Hitzel, D. Brasse, and P. Vera
Effect of Perfusion Pattern and Imaging Sequence on Gated Perfusion SPECT Evaluation of Myocardial Stunning
J. Nucl. Med., January 1, 2005; 46(1): 176 - 183.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
N K Sabharwal and A Lahiri
Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease
Heart, November 1, 2003; 89(11): 1291 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
N. Shirai, H. Yamagishi, M. Yoshiyama, M. Teragaki, K. Akioka, K. Takeuchi, J. Yoshikawa, and H. Ochi
Incremental Value of Assessment of Regional Wall Motion for Detection of Multivessel Coronary Artery Disease in Exercise 201Tl Gated Myocardial Perfusion Imaging
J. Nucl. Med., April 1, 2002; 43(4): 443 - 450.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
L. Emmett, R. M. Iwanochko, M. R. Freeman, A. Barolet, D. S. Lee, and M. Husain
Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses
J. Am. Coll. Cardiol., March 20, 2002; 39(6): 991 - 998.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
H. Yamagishi, N. Shirai, M. Yoshiyama, M. Teragaki, K. Akioka, K. Takeuchi, J. Yoshikawa, and H. Ochi
Incremental Value of Left Ventricular Ejection Fraction for Detection of Multivessel Coronary Artery Disease in Exercise 201Tl Gated Myocardial Perfusion Imaging
J. Nucl. Med., February 1, 2002; 43(2): 131 - 139.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. T. Mast, L. K. Shaw, G. C. Ravizzini, M. Chambless, P. Joski, R. E. Coleman, and S. Borges-Neto
Incremental Prognostic Value of RNA Ejection Fraction Measurements During Pharmacologic Stress Testing: A Comparison with Clinical and Perfusion Variables
J. Nucl. Med., June 1, 2001; 42(6): 871 - 877.
[Abstract] [Full Text] [PDF]