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(Radiology. 2000;215:858-862.)
© RSNA, 2000

Experimental Studies

Human Fetal Lung Fibroblasts: In Vitro Study of Repetitive Magnetic Field Exposure at 0.2, 1.0, and 1.5 T1

Jakub Wiskirchen, MD, Eckart F. Grönewäller, MD, Frank Heinzelmann, Rainer Kehlbach, PhD, Enno Rodegerdts, MD, Matthias Wittau, H. Peter Rodemann, PhD, Claus D. Claussen, MD and Stephan H. Duda, MD

1 From the Departments of Diagnostic Radiology (J.W., E.F.G., F.H., R.K., E.R., M.W., C.D.C., S.H.D.) and Radiotherapy, Section of Radiobiology and Environmental Research (H.P.R.), Eberhard-Karls-Universität, Hoppe-Seyler-St 3, 72076 Tüebingen, Germany. Received February 26, 1999; revision requested April 28; final revision received September 14; accepted October 4. Supported in part by grant no. 257 from the forüne research program, University of Tüebingen, Germany. Address correspondence to J.W. (e-mail: jakub.wiskirchen@uni-tuebingen.de).

PURPOSE: To evaluate whether repetitive exposure to magnetic fields of 0.2, 1.0, and 1.5 T affect the growth of human fetal lung fibroblasts (HFLFs).

MATERIALS AND METHODS: Cultured HFLFs were exposed to static magnetic fields of 0.2, 1.0, and 1.5 T for 1 h/d for 5 consecutive days. Control groups were kept under identical environmental conditions, apart from the magnetic field, during the experiments. Cell cycle analysis for synchronously and nonsynchronously growing cells was performed. Population doublings (PDs) were calculated. To rule out midterm effects, proliferation kinetics of the cells were analyzed for 21 days.

RESULTS: Cell cycle analysis of synchronized and nonsynchronized cells did not reveal statistically significant differences between the exposed and control cells. The PDs did not indicate any growth modulation during exposure. Proliferation kinetics did not provide any hint of midterm growth modulation effects of repetitive magnetic field exposure.

CONCLUSION: Repetitive magnetic field exposure does not exert any growth-modulating effect on overall cell growth and cell cycle distribution of cultured HFLFs. Midterm effects due to magnetic field exposure were not found.

Index terms: Magnetic resonance (MR), biological effects • Magnetic resonance (MR), experimental studies • Magnetic resonance (MR), safety • Radiobiology, cell and tissue studies




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