HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tseng, W.-Y. I. Articles by Wedeen, V. J. Search for Related Content PubMed PubMed Citation Articles by Tseng, W.-Y. I. Articles by Wedeen, V. J.

Myocardial Fiber Shortening in Humans: Initial Results of MR Imaging¹

¹ From the Department of Radiology, National Taiwan University Medical College, Laser Medical Research Center, Taipei, Taiwan (W.Y.I.T.); and the Department of Radiology, NMR Center, Massachusetts General Hospital-East, Bldg 149, 13th St, Charlestown, MA 02129 (T.G.R., R.M.W., T.J.B., V.J.W). Received July 16, 1999; revision requested August 17; revision received October 7; accepted October 25. Supported by National Institutes of Health 1RO1-HL56737 grant (V.J.W., W.Y.I.T.), the American Heart Association Established Investigator Grant 9740208N (V.J.W.), and grants from the New York Cardiac Center and the Sol Goldman Charitable Trust (V.J.W.). Address correspondence to V.J.W. (e-mail: van@nmr.mgh.harvard.edu).

PURPOSE: To use diffusion-sensitive magnetic resonance (MR) imaging to obtain images of fiber orientation in vivo and to map fiber shortening in humans by means of integrating such data with strain images.

MATERIALS AND METHODS: Images of fiber shortening for midventricular short-axis sections were acquired in eight healthy subjects. Fiber orientation maps obtained by means of diffusion-sensitive MR imaging were coregistered with systolic strain maps obtained by means of velocity-sensitive MR imaging. Fiber shortening was quantified by use of the component of systolic strain in the fiber direction.

RESULTS: The results were reproducible among subjects and were consistent with published values. MR imaging of myocardial fibers showed axisymmetric progression of fiber angles from -90° epicardially to +90° endocardially, with maxima near 0°. Fiber shortening (mean, 0.12 ± 0.01 [SD]) was more uniform than radial, circumferential, longitudinal, or cross-fiber strain or any principal strain. Fiber orientation coincided with the direction of maximum contraction epicardially, with that of minimum contraction endocardially, and varied between these extremes linearly with wall depth (r = 0.6).

CONCLUSION: Registered diffusion and strain MR imaging can be used quantitatively to map fiber orientation and its relations to myocardial deformation in humans.

Index terms: Heart, function, 51.91, 51.92 • Heart, MR, 51.121411, 51.121416, 51.12144 • Magnetic resonance (MR), diffusion study, 51.12144 • Magnetic resonance (MR), phase imaging, 51.121411, 51.121416 • Myocardium, MR, 511.121411, 511.121416, 511.12144

This article has been cited by other articles:

				H. Wen, K. A. Marsolo, E. E. Bennett, K. S. Kutten, R. P. Lewis, D. B. Lipps, N. D. Epstein, J. F. Plehn, and P. Croisille Adaptive Postprocessing Techniques for Myocardial Tissue Tracking with Displacement-encoded MR Imaging Radiology, January 1, 2008; 246(1): 229 - 240. [Abstract] [Full Text] [PDF]

				S. H. Gilbert, A. P. Benson, P. Li, and A. V. Holden Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure Eur. J. Cardiothorac. Surg., August 1, 2007; 32(2): 231 - 249. [Abstract] [Full Text] [PDF]

				S. M. Felton, T. A. Gaige, T. G. Reese, V. J. Wedeen, and R. J. Gilbert Mechanical basis for lingual deformation during the propulsive phase of swallowing as determined by phase-contrast magnetic resonance imaging J Appl Physiol, July 1, 2007; 103(1): 255 - 265. [Abstract] [Full Text] [PDF]

				M.-T. Wu, W.-Y. I. Tseng, M.-Y. M. Su, C.-P. Liu, K.-R. Chiou, V. J. Wedeen, T. G. Reese, and C.-F. Yang Diffusion Tensor Magnetic Resonance Imaging Mapping the Fiber Architecture Remodeling in Human Myocardium After Infarction: Correlation With Viability and Wall Motion Circulation, September 5, 2006; 114(10): 1036 - 1045. [Abstract] [Full Text] [PDF]

				F. Carreras, M. Ballester, S. Pujadas, R. Leta, and G. Pons-Llado Morphological and functional evidences of the helical heart from non-invasive cardiac imaging Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S50 - S55. [Abstract] [Full Text] [PDF]

				P. P. Sengupta, B. K. Khandheria, J. Korinek, J. Wang, and M. Belohlavek Biphasic tissue Doppler waveforms during isovolumic phases are associated with asynchronous deformation of subendocardial and subepicardial layers J Appl Physiol, September 1, 2005; 99(3): 1104 - 1111. [Abstract] [Full Text] [PDF]

				D J Sahn and G W Vick III Review of new techniques in echocardiography and magnetic resonance imaging as applied to patients with congenital heart disease Heart, December 1, 2001; 86(90002): ii41 - 53. [Full Text] [PDF]