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(Radiology. 2000;216:220-224.)
© RSNA, 2000

Experimental Studies

Selenium-based Digital Radiography in the Detection of Bone Lesions: Preliminary Experience with Experimentally Created Defects1

Karl Ludwig, MD, Thomas M. Link, MD, Martin Fiebich, PhD, Bernhard Renger, MS, Stefan Diederich, MD, Michael Oelerich, MD, Horst Lenzen, MS and Walter Heindel, MD

1 From the Department of Clinical Radiology, University of Muenster, Albert Schweitzer Strasse 33, D-48129 Muenster, Germany. Received July 8, 1999; revision requested August 25; revision received October 12; accepted November 22. Address correspondence to K.L. (e-mail: lud@uni-muenster.de).

PURPOSE: To compare the diagnostic performance of selenium-based digital radiography with that of conventional screen-film radiography and storage phosphor radiography for the detection of bone lesions simulating osteolyses.

MATERIALS AND METHODS: Artificial osseous lesions 1.0–3.0 mm in diameter were created in 80 of 160 predefined regions in 16 porcine femoral specimens. Specimens were enclosed in containers filled with paraffin to ensure accurate repositioning and to obtain an absorption condition comparable to that of a human extremity. Imaging was performed with a selenium-based digital radiography system, a conventional screen-film system, and a storage phosphor radiography system with an exposure identical to that used during clinical imaging. The presence of a lesion was assessed with a five-point confidence scale. Receiver operating characteristic (ROC) analysis was performed for a total of 1,440 observations (480 per modality), and diagnostic performance was estimated with the area under the ROC curve (Az). Differences in diagnostic performance were assessed with the paired Student t test.

RESULTS: ROC analysis results showed Az values of 0.656 for selenium-based digital radiography, 0.679 for storage phosphor radiography, and 0.680 for conventional screen-film radiography. Differences between the three modalities were not significant (P = .60–.93).

CONCLUSION: Image quality with selenium-based digital radiography was comparable to that with conventional screen-film radiography and storage phosphor radiography.

Index terms: Animals • Bones, radiography, 451.11, 451.1215, 451.1219 • Femur, abnormalities, 451.1869 • Radiography, comparative studies, 451.11, 451.1215, 451.1219 • Radiography, digital, 451.1215 • Radiography, selenium detector, 451.1219 • Radiography, storage phosphor, 451.1219 • Selenium




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