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(Radiology. 2000;216:225-231.)
© RSNA, 2000

Experimental Studies

MR Imaging of Nitrosyl-Iron Complexes: Experimental Study in Rats1

Birgit Fichtlscherer, MSc and Alexander Mülsch, PhD

1 From Institut für Kardiovaskuläre Physiologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany. Received March 1, 1999; revision requested April 5; final revision received October 25; accepted November 16. Supported by the German Science Foundation, SFB 553. Address correspondence to A.M. (e-mail: muelsch@em.uni-frankfurt.de).

PURPOSE: To assess the influence of several nitrosyl-iron complexes on proton nuclear spin relaxation rates to establish a magnetic resonance (MR) imaging technique for nitric oxide.

MATERIALS AND METHODS: The influence of aqueous phantom solutions of nitrosyl-iron complexes on proton relaxation rates was analyzed for signal enhancement at conventional 1.5-T MR imaging. To induce formation of nitrosyl-iron complexes in a biologic tissue, isolated rat liver was perfused with a saline solution of the NO donor sodium nitroprusside (SNP), and the MR signal intensity was examined thereafter.

RESULTS: All investigated nitrosyl-iron complexes shortened the longitudinal, or T1, and transverse, or T2, relaxation times in a concentration-dependent fashion. Relaxivities were highest with a dinitrosyl-iron complex bound to albumin and with a water-soluble mononitrosyl-iron dithiocarbamate complex. The contrast properties of 240 µmol/L of a paramagnetic nitrosyl-iron complex were sufficient to substantially enhance the signal intensity of SNP-perfused rat livers at hydrogen 1 MR imaging.

CONCLUSION: Nitrosyl-iron complexes exhibit a contrast effect at MR imaging that can be exploited for NO imaging in living animals and patients with conventional 1H MR imaging techniques.

Index terms: Animals • Iron • Magnetic resonance (MR), contrast enhancement, 761.12143 • Magnetic resonance (MR), experimental studies, 761.12141 • Magnetic resonance (MR), relaxometry, 761.12146 • Nitrosyl-iron complex, 761.12143 • Phantoms




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