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B-Mode Enhancement at Phase-Inversion US with Air-based Microbubble Contrast Agent: Initial Experience in Humans¹

¹ From the Department of Radiology and Nuclear Medicine, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany (T.A., C.W.H., S.S., A.O., K.J.W.); the Department of Clinical Development, Schering, Berlin, Germany (A.B.); and Siemens US Group, Issaquah, Wash (M.I., P.L.v.B.). Received June 14, 1999; revision requested July 22; revision received October 12; accepted November 16. Address correspondence to T.A. (e-mail: t.albrecht@medizin.fu-berlin.de).

Pulse- or phase-inversion ultrasonography (US) sums the signals returned from two 180° ultrasound pulses. Linear scattering from tissue results in a signal void while nonlinear signals from microbubbles stand out. The technique was applied with a US contrast agent in 39 human subjects. B-mode enhancement of vessels and organ parenchyma was seen in all cases. Enhancement occurred from flowing and stationary microbubbles. The flow-independent enhancement of normal and abnormal tissue represents a major advance in contrast material–enhanced US with many potential applications especially in tumor imaging.

Index terms: Ultrasound (US), contrast media, 9_*.12988²

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