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Technical Developments |
1 From the Department of Neurology (R.E.H.) and the Division of Neurosurgery (R.D.B.), Saint Louis University, 3635 Vista Ave, St Louis, MO 63110; IntellX, Broomfield, Colo (K.E.M., S.J., R.D.B.); the Department of Psychiatry, Washington University School of Medicine, St Louis, Mo (L.W.); and the Center for Imaging Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Md (M.I.M.). Received May 17, 1999; revision requested July 19; final revision received October 12; accepted October 26. Address correspondence to R.E.H. (e-mail: hoganr2@slu.edu).
In five patients with mesial temporal sclerosis, the authors verified the precision and reproducibility of hippocampal segmentations with deformation-based magnetic resonance (MR) imaging. The overall percentage overlap between automated segmentations was 92.8% (SD, 3.5%), between manual segmentations was 73.1% (SD, 9.5%), and between automated and manual segmentations was 74.8% (SD, 10.3%). Deformation-based hippocampal segmentations provided a precise method of hippocampal volume measurement in this patient population.
Index terms: Brain, volume, 1341.839 • Epilepsy • Hippocampus, 1341.92 • Magnetic resonance (MR), image processing, 1341.121412 • Magnetic resonance (MR), volume measurement, 1341.12141 • Schizophrenia
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