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Neuroradiology |
1 From the Neuroimaging Research/Radiology Service (H.K., K.I.) and Clinical Neurosciences/Neurology and Neurorehabilitation Services (E.M., N.H.), Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan. Received May 4, 1999; revision requested July 14; revision received August 31; accepted September 20. Address correspondence to H.K., Department of Radiology, Shimane Medical University, 89-1 Enya-Cho Izumo 693-8501, Japan. (e-mail: kitagaki@shimane-med.ac.jp).
PURPOSE: To determine the characteristics of cortical atrophy in corticobasal degeneration and Alzheimer disease by using a hemispheric surface display generated with magnetic resonance (MR) images.
MATERIALS AND METHODS: The magnitude and extent of cortical atrophy were evaluated with MR hemispheric surface display and volumetric measurement in three groups: 17 patients with corticobasal degeneration, 17 matched patients with Alzheimer disease, and 17 matched healthy control subjects.
RESULTS: The extent and magnitude of cortical atrophy were larger in the group with corticobasal degeneration than in the group with Alzheimer disease. The parasagittal and paracentral regions were significantly more atrophic in patients with corticobasal degeneration than in patients with Alzheimer disease (P < .05). The mean hemispheric-to-total intracranial volume ratios were significantly smaller in the patients with corticobasal degeneration (61%) and those with Alzheimer disease (64%) than in control subjects (69%). Asymmetry of hemispheric volume was significantly larger in the group with corticobasal degeneration than in the control group.
CONCLUSION: The extent of cortical atrophy in corticobasal degeneration is more widespread than was previously thought. Parasagittal and paracentral atrophy is a distinctive feature of corticobasal degeneration and distinguishes it from Alzheimer disease.
Index terms: Alzheimer disease, 13.83 • Brain, atrophy, 13.83 • Brain, MR, 13.121412, 13.121419 • Brain, PET, 13.12163 • Brain, SPECT, 13.12162 • Brain, volume, 13.12144 • Dementia, 13.83 • Magnetic resonance (MR), image processing, 13.121419, 13.12144 • Magnetic resonance (MR), three-dimensional, 13.121419 • Magnetic resonance (MR), volume measurement, 13.12144
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