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(Radiology. 2000;216:78-85.)
© RSNA, 2000


Vascular and Interventional Radiology

Stent Placement for Renal Arterial Stenosis: Where Do We Stand? A Meta-analysis1

Trude C. Leertouwer, MSc, Elma J. Gussenhoven, MD, Johanna L. Bosch, PhD, Brigit C. van Jaarsveld, MD, Lukas C. van Dijk, MD, Jaap Deinum, MD and Arie J. Man in 't Veld, MD

1 From the Departments of Radiology (T.C.L., L.C.v.D.), Internal Medicine (T.C.L., B.C.v.J., J.D., A.J.M.i.t.V.), Cardiology (E.J.G.), Epidemiology and Biostatistics (J.L.B.), and the Interuniversity Cardiology Institute of the Netherlands (E.J.G.), Erasmus University Rotterdam (Ee 2312), Dr. Molewaterplein 50, 3015 GE Rotterdam, the Netherlands; and the Department of Health Policy and Management, Keio University, Tokyo, Japan (J.L.B.). Received January 27, 1999; revision requested April 1; final revision received September 29; accepted October 25. T.C.L. supported in part by grants from a Revolving Fund (1996-26) of the Erasmus University Medical Center Rotterdam and Cordis, a Johnson & Johnson Company; E.J.G. supported in part by a grant from the Interuniversity Cardiology Institute of the Netherlands. Address correspondence to E.J.G. (e-mail: leertouwer@tch.fgg.eur.nl).

PURPOSE: To perform a meta-analysis of renal arterial stent placement in comparison with renal percutaneous transluminal angioplasty (PTA) in patients with renal arterial stenosis.

MATERIALS AND METHODS: Studies dealing with renal arterial stent placement (14 articles; 678 patients) and renal PTA (10 articles; 644 patients) published up to August 1998 were selected. A random-effects model was used to pool the data.

RESULTS: Renal arterial stent placement proved highly successful, with an initial adequate performance in 98% and major complications in 11%. The overall cure rate for hypertension was 20%, whereas hypertension was improved in 49%. Renal function improved in 30% and stabilized in 38% of patients. The restenosis rate at follow-up of 6–29 months was 17%. Stent placement had a higher technical success rate and a lower restenosis rate than did renal PTA (98% vs 77% and 17% vs 26%, respectively; P < .001). The complication rate was not different between the two treatments. The cure rate for hypertension was higher and the improvement rate for renal function was lower after stent placement than after renal PTA (20% vs 10% and 30% vs 38%, respectively; P < .001).

CONCLUSION: Renal arterial stent placement is technically superior and clinically comparable to renal PTA alone.

Index terms: Arteries, grafts and prostheses, 961.1286 • Hypertension, renovascular, 81.72 • Renal arteries, stenosis or obstruction, 961.72 • Renal arteries, transluminal angioplasty, 961.454 • Stents and prostheses, 961.1286




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