| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Genitourinary Imaging |
1 From the Departments of Radiology (K.A.F., K.K., H.M.B., Y.L., H.H.) and Pathology (C.Z.), the University of California, San Francisco. From the 1999 RSNA scientific assembly. Received August 6, 1999; revision requested September 29; revision received October 28; accepted November 2. Address correspondence to H.H., Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021.
PURPOSE: To determine if, in a patient with an endometrial cancer, in addition to the knowledge of tumor grade, preoperative magnetic resonance (MR) imaging findings contribute to treatment stratification and specialist referral.
MATERIALS AND METHODS: By using a MEDLINE literature search and institutional pathology reports, pretest probabilities for myometrial invasion were correlated with tumor grade. Likelihood ratios (LRs) were obtained through summary receiver operating characteristics.
RESULTS: The mean pretest probabilities of deep myometrial invasion were derived from seven articles (1,875 patients) and from 125 institutional pathology reports. LRs for the prediction of myometrial invasion with contrast-enhanced MR imaging were derived from nine studies (742 patients); positive and negative LRs were 10.11 and 0.1, respectively. The mean weighted pretest probabilities of deep myometrial invasion in patients with tumor grades 1, 2, or 3 were 13%, 35%, or 54%, respectively. Posttest probabilities of deep myometrial invasion for grades 1, 2, or 3 increased to 60%, 84%, or 92%, respectively, for positive and decreased to 1%, 5%, or 10%, respectively, for negative MR imaging findings.
CONCLUSION: Use of contrast-enhanced MR imaging significantly affects the posttest probability of deep myometrial invasion in patients with all grades of endometrial cancer and could be used to select patients for specialist referral.
Index terms: Uterine neoplasms, 854.32, 854.3231, 854.324 • Uterine neoplasms, MR, 854.12143 • Uterus, MR, 854.12143
This article has been cited by other articles:
|
|
 |
|
  G. Lin, K.-K. Ng, C.-J. Chang, J.-J. Wang, K.-C. Ho, T.-C. Yen, T.-I Wu, C.-C. Wang, Y.-R. Chen, Y.-T. Huang, et al. Myometrial Invasion in Endometrial Cancer: Diagnostic Accuracy of Diffusion-weighted 3.0-T MR Imaging--Initial Experience Radiology, March 1, 2009; 250(3): 784 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Torricelli, S. Ferraresi, F. Fiocchi, G. Ligabue, V. M. Jasonni, I. Di Monte, and F. Rivasi 3-T MRI in the Preoperative Evaluation of Depth of Myometrial Infiltration in Endometrial Cancer Am. J. Roentgenol., February 1, 2008; 190(2): 489 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sala, S. Wakely, E. Senior, and D. Lomas MRI of Malignant Neoplasms of the Uterine Corpus and Cervix Am. J. Roentgenol., June 1, 2007; 188(6): 1577 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Bidus, J. I. Risinger, G. V.R. Chandramouli, L. A. Dainty, T. J. Litzi, A. Berchuck, J. C. Barrett, and G. L. Maxwell Prediction of Lymph Node Metastasis in Patients with Endometrioid Endometrial Cancer Using Expression Microarray Clin. Cancer Res., January 1, 2006; 12(1): 83 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Manfredi, P. Mirk, G. Maresca, P. A. Margariti, A. Testa, G. F. Zannoni, D. Giordano, G. Scambia, and P. Marano Local-Regional Staging of Endometrial Carcinoma: Role of MR Imaging in Surgical Planning Radiology, May 1, 2004; 231(2): 372 - 378. [Abstract] [Full Text] [PDF]
|
|
