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Patients with Pulmonary Fibrosis: Cardiac Function Assessed with MR Imaging¹

¹ From the Departments of Radiology (L.J.M.K., P.S., A.d.R.) and Rheumatology (J.M.v.L.), C2-S, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Received May 13, 1999; revision requested July 13; revision received October 18; accepted December 30, 2000. Address correspondence to A.d.R. (e-mail: a.de_roos@radiology.azl.nl).

PURPOSE: To detect abnormalities in cardiac function by using magnetic resonance (MR) imaging in patients with mild to moderate pulmonary fibrosis and to evaluate the relationship between pulmonary function and cardiac function.

MATERIALS AND METHODS: Sixteen patients were compared with 16 sex- and age-matched healthy control subjects. Systolic function was assessed by using multisection multiphase cine MR imaging. Diastolic function was assessed with flow-sensitive MR imaging across the mitral and tricuspid valves. MR imaging results were compared with the severity of impairment in pulmonary function.

RESULTS: Biventricular systolic function and left ventricular diastolic function were normal in patients, but right ventricular diastolic function was significantly impaired versus that of control subjects, with a ratio of peak flow during early diastolic (E) filling to peak flow during atrial contraction (A) of 0.85 ± 0.40 versus 1.28 ± 0.50 (P = .035). Biventricular E/A ratios were strongly correlated to age in patients and control subjects. The right ventricular E/A ratio in patients corresponded with values that are normally expected in people 20 years older. Diastolic left and right ventricular functions were significantly correlated with each other. There was no relationship between pulmonary function and cardiac function.

CONCLUSION: Impairment of right ventricular diastolic function was found by using MR imaging in patients with mild to moderate pulmonary fibrosis, whereas left ventricular diastolic function and biventricular systolic function were preserved.

Index terms: Heart, function • Heart, MR, 51.121412, 51.121416, 51.12144 • Heart, ventricles • Lung, fibrosis, 60.6113 • Lung, function • Magnetic resonance (MR), cine study, 51.121412, 51.12144 • Magnetic resonance (MR), functional imaging, 51.12144 • Magnetic resonance (MR), volume measurements, 51.121412, 51.12144

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