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Experimental Studies |
1 From the Department of Radiology, University of California, 505 Parnassus Ave, San Francisco, CA 94143-0628. Received March 3, 1999; revision requested April 27; revision received October 28; accepted November 2. Supported in part by a research grant from Nycomed Amersham Imaging, Oslo, Norway. J.B. supported by the ADUMED Foundation, Gentilino, Switzerland. Address correspondence to M.F.W. (e-mail: mike.wendland@radiology.ucsf.edu).
PURPOSE: To assess whether normal myocardium can be distinguished from infarction at magnetic resonance (MR) imaging with low doses of manganese dipyridoxyl diphosphate (Mn-DPDP).
MATERIALS AND METHODS: After 1-hour coronary arterial occlusion and 2-hour reperfusion, three groups of eight rats each were injected with 25, 50, or 100 µmol of Mn-DPDP per kilogram of body weight. The longitudinal relaxation rate (R1) in normal myocardium, reperfused infarction, and blood was repeatedly measured at inversion-recovery echo-planar imaging before and for 1 hour after the administration of contrast material. Afterward, several animals from each group were examined at high-spatial-resolution inversion-recovery spin-echo (SE) MR imaging.
RESULTS: Manganese accumulated in normal myocardium but was cleared from reperfused infarction and blood. One hour after the administration of Mn-DPDP, R1 in normal myocardium (1.53 sec-1 ± 0.03, 1.73 sec-1 ± 0.03, and 1.94 sec-1 ± 0.02, respectively, for 25, 50, and 100 µmol/kg) was significantly (P < .05) faster than that of reperfused infarction (0.99 sec-1 ± 0.03, 1.11 sec-1 ± 0.03, and 1.48 sec-1 ± 0.06). Normal myocardium appeared hyperintense on T1-weighted inversion-recovery SE MR images and was clearly distinguishable from reperfused infarction.
CONCLUSION: Mn-DPDP–enhanced inversion-recovery echo-planar and SE MR images demonstrated retention of manganese in normal myocardium and clearance of manganese from infarction. Mn-DPDP has characteristics similar to those of widely used thallium and may be useful in the assessment of myocardial viability at MR imaging.
Index terms: Animals • Magnetic resonance (MR), contrast enhancement, 511.12143 • Magnetic resonance (MR), echo planar, 511.121416 • Magnetic resonance (MR), inversion recovery, 511.121413 • Manganese • Myocardium, infarction, 511.771 • Myocardium, MR, 511.121411, 511.121413, 511.121415, 511.121416, 511.12143, 511.12146
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