HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kubik-Huch, R. A. Articles by Debatin, J. F. Search for Related Content PubMed PubMed Citation Articles by Kubik-Huch, R. A. Articles by Debatin, J. F. Related Collections Related Article

Gadopentetate Dimeglumine Excretion into Human Breast Milk during Lactation¹

¹ From the Department of Radiology (R.A.K.H., N.M.G.A., J.F.D.) and Clinic for Obstetrics (S.W.), University Hospital Zurich, Römistrasse 100, CH-8091 Zurich, Switzerland; Schering, Berlin, Germany (T.F., E.P.); and the Department of Biostatistics, University of Zürich, Switzerland (B.S.). Received September 30, 1999; revision requested November 15; revision received December 10; accepted December 16. Supported in part by Schering, Berlin, Germany. Address correspondence to R.A.K.H. (e-mail: rahel.kubik@dmr.usz.ch).

PURPOSE: To analyze the amount of gadopentetate dimeglumine excreted into human breast milk following intravenous injection of a clinical dose.

MATERIALS AND METHODS: Gadopentetate dimeglumine was injected intravenously in 20 lactating women (23–38 years of age). Breast-feeding was interrupted for at least 24 hours. Serial samples of expressed milk were collected and analyzed for gadolinium concentration by means of inductively coupled plasma atomic emission spectrometry at a wavelength of 342.247 nm.

RESULTS: The cumulative amount of gadolinium excreted in human breast milk during 24 hours was 0.57 µmol ± 0.71 (SD; range, 0.05–3.0 µmol). The excreted dose was thus less than 0.04% of the administered intravenous dose (range, 0.001%–0.04%; mean, 0.009% ± 0.010) for all cases.

CONCLUSION: Less than 0.04% of administered gadopentetate dimeglumine is excreted into human breast milk. The amount transferred to a nursing infant orally would be far more than 100 times less than the permitted intravenous dose (200 µmol per kilogram of body weight) for neonates. The recommendation of a 24-hour suspension of breast-feeding for lactating women should thus be reconsidered.

Index terms: Breast • Contrast media, complications, _**.12143³, _**.58 • Contrast media, effects, _**.12143, _**.58 • Contrast media, toxicity, _**.12143, _**.58 • Gadolinium, _**.12143 • Infants, newborn • Magnetic resonance (MR), contrast media, _**.12143

Related Article

Suspension of Breast-feeding following Gadopentetate Dimeglumine Administration

Nola M. Hylton
Radiology 2000 216: 325-326. [Full Text] [PDF]

This article has been cited by other articles:

				J. Newman Breastfeeding and radiologic procedures Can Fam Physician, April 1, 2007; 53(4): 630 - 631. [Abstract] [Full Text] [PDF]

				L. A. Espinosa, B. L. Daniel, L. Vidarsson, M. Zakhour, D. M. Ikeda, and R. J. Herfkens The Lactating Breast: Contrast-enhanced MR Imaging of Normal Tissue and Cancer Radiology, November 1, 2005; 237(2): 429 - 436. [Abstract] [Full Text] [PDF]

				J. R. Leyendecker, V. Gorengaut, and J. J. Brown MR Imaging of Maternal Diseases of the Abdomen and Pelvis during Pregnancy and the Immediate Postpartum Period RadioGraphics, September 1, 2004; 24(5): 1301 - 1316. [Abstract] [Full Text] [PDF]

				N. M. Hylton Suspension of Breast-feeding following Gadopentetate Dimeglumine Administration Radiology, August 1, 2000; 216(2): 325 - 326. [Full Text]