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(Radiology. 2000;216:592-596.)
© RSNA, 2000


Technical Developments

Liver Lesions: Intermittent Second-Harmonic Gray-Scale US Can Increase Conspicuity with Microbubble Contrast Material-Early Experience1

Rolf A. Heckemann, DM, David O. Cosgrove, FRCR, Martin J. K. Blomley, FRCR, Robert J. Eckersley, PhD, Christopher J. Harvey, FRCR and Yoshitaka Mine, MS

1 From the Department of Imaging, Hammersmith Hospital, Du Cane Road, London W12 0HS, United Kingdom (R.A.H., D.O.C., M.J.K.B., R.J.E., C.J.H.), and Toshiba Medical Systems, Tokyo, Japan (Y.M.). Received June 24, 1999; revision requested August 30; revision received October 28; accepted November 1. M.J.K.B. and C.J.H. supported by grants from the Medical Research Council, London, England. R.J.E. supported by a grant from Schering, Berlin, Germany. Address correspondence to R.A.H. (e-mail: soundray@web.de).

The authors investigated the effect of intermittent second-harmonic gray-scale (ISHGS) ultrasonography (US) with SH U 508A microbubbles on the conspicuity of focal liver lesions. Twenty-three patients were included in the study. Images were analyzed subjectively and quantitatively. Objective lesion conspicuity was increased. In 12 of the 15 patients with liver malignancy, gray-scale defects were seen in previously unsuspected areas. ISHGS US may improve the sensitivity of US for liver lesions.

Index terms: Liver neoplasms, metastases, 761.33 • Liver neoplasms, US, 761.12988, 761.32 • Ultrasound (US), contrast media, 761.12988 • Ultrasound (US), harmonic study, 761.12988, 761.12989 • Ultrasound (US), technology, 761.12988




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