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Experimental Studies |
1 From the Laboratories of Experimental Radiology and Synovial Pathology (V.B., C.B., F.B., C.P.C., A.M.L.J., J.D.L.) and Orthopedic Research (Pr Laurent Sedel) (A.M.), Faculty of Medicine, Lariboisière-Saint-Louis, 10, avenue de Verdun, 75010 Paris, France; and the Department of Musculoskeletal Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisière, France (V.B., C.P.C., J.D.L.). Received September 15, 1999; revision requested October 21; revision received January 4, 2000; accepted February 11. Supported in part by the Assistance Publique-Hôpitaux de Paris, France, and the Centre National de la Recherche Scientifique, Paris, France. Address correspondence to V.B. (e-mail: vbousson@free.fr).
PURPOSE: To determine whether computed tomography (CT) can be used to quantify age- and site-related changes in cortical bone mineral density (cBMD) at the middiaphyseal femur and whether cBMD differences are related to intracortical porosity.
MATERIALS AND METHODS: Cortical bone specimens from 163 femurs were studied with CT and microradiography. Femurs were from 77 males and 86 females in a white anthropologic collection covering a broad age spectrum. In each sample, the cBMD was measured in the entire cortical width and in periosteal, midcortical, and endosteal subregions of interest. Age- and site-related changes in cBMD were tested for significance by using a two-way analysis of variance for both sexes. By using linear regression, cBMD was compared with porosity in the entire cortical width and in each subregion.
RESULTS: There were significant age-related differences in cBMD (P < .001 in females, P = .008 in males). In addition, cBMD values were significantly different between the three cortical subregions (P < .001 for both sexes), decreasing from the periosteum to the midcortex to the endosteum. The cBMD values were closely related to porosity, and porosity contributed to 71.6% of the variance in cBMD in the overall population.
CONCLUSION: CT is effective in the measurement of age- and site-related changes in cBMD. Decreases in cBMD are closely correlated with increased cortical porosity.
Index terms: Bones, mineralization, 444.1295, 444.56 • Bones, radiography, 444.123, 444.1292 • Computed tomography (CT), quantitative, 444.1211, 444.123 • Femur, CT, 444.1211 • Osteoporosis, 444.56
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