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Cardiac Imaging |
1 From the Cardiac Rehabilitation Institute (J.S., C.I.S., M.M.) and Department of Diagnostic Imaging (S.A., Y.I.), Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. From the 1999 RSNA scientific assembly. Received January 12, 2000; revision requested February 9; revision received March 21; accepted April 4. Address correspondence to J.S. (e-mail: dshemesh@netvision.net.il).
PURPOSE: To investigate the accuracy of dual-section spiral computed tomography (CT) in tracking the progression of coronary calcification, as measured during a 3-year follow-up.
MATERIALS AND METHODS: Two hundred forty-six patients with hypertension (mean age, 66 years ± 6 [SD]) were preselected in accordance with the International Nifedipine Study Intervention as a Goal for Hypertension Therapy protocol. Subjects had no clinical coronary arterial disease prior to the study and no cardiovascular events during follow-up. All participants underwent baseline CT (3.2-mm section thickness; reconstruction increment, 1.5 mm) and follow-up CT after 3 years. Calcification progression was defined as any increase in total calcification score (TCS) and analyzed in accordance with five baseline TCS categories: 1–9, 10–35, 36–100, 101–250, and greater than 250.
RESULTS: At baseline CT, 152 patients had a TCS greater than 0, and 106 (70%) showed progression after 3 years, while 94 had a baseline TCS of 0; of these, 26 (28%) showed progression (P < .01 between groups). The mean TCS was significantly higher in each baseline TCS category after 3 years. The percentage increase was negatively correlated with baseline TCS (P < .01) and ranged from 466% in the lowest category to 38% in the highest.
CONCLUSION: Dual-section spiral CT depicts significant change in TCS over time and is useful in tracking calcified coronary atherosclerosis.
Index terms: Arteriosclerosis, 51.81, 54.81 • Computed tomography (CT), 51.12115, 54.12115 • Computed tomography (CT), helical, 51.12115 • Coronary vessels, calcification, 54.81 • Heart, CT, 51.12115
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