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(Radiology. 2000;217:633-646.)
© RSNA, 2000

State of the Art

Tumor Ablation with Radio-frequency Energy1

G. Scott Gazelle, MD, MPH, PhD, S. Nahum Goldberg, MD, Luigi Solbiati, MD and Tito Livraghi, MD

1 From the Decision Analysis and Technology Assessment Group, Department of Radiology, Massachusetts General Hospital, Zero Emerson Pl, Ste 2H, Boston, MA 02114 (G.S.G.); the Department of Health Policy and Management, Harvard School of Public Health, Boston, Mass (G.S.G.); the Minimally Invasive Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Mass (S.N.G.); the Department of Radiology, General Hospital, Busto Arsizio, Italy (L.S.); and the Department of Radiology, Ospedale Civile, Vimercate, Milan, Italy (T.L.). Received August 11, 1999; revision requested September 24; revision received November 16; accepted December 6; updated July 26, 2000. S.N.G. supported by research funding from Radionics. Address correspondence to. G.S.G. (e-mail: gazelle@nmr.mgh.harvard.edu).

Tumor ablation by using radio-frequency energy has begun to receive increased attention as an effective minimally invasive approach for the treatment of patients with a variety of primary and secondary malignant neoplasms. To date, these techniques have been used to treat tumors located in the brain, musculoskeletal system, thyroid and parathyroid glands, pancreas, kidney, lung, and breast; however, liver tumor ablation has received the greatest attention and has been the subject of a large number of published reports. In this article, the authors review the technical developments and early laboratory results obtained with radio-frequency ablation techniques, describe some of the early clinical applications of these techniques, and conclude with a discussion of challenges and opportunities for the future.

Index terms: Interventional procedures, technology • Interventional procedures, utilization, **.12692 • Radiofrequency (RF) ablation, **.1269 • State of the Art




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