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(Radiology. 2000;217:665-672.)
© RSNA, 2000

Vascular and Interventional Radiology

Radio-frequency Ablation of Renal Cell Carcinoma: Early Clinical Experience1

Debra A. Gervais, MD, Francis J. McGovern, MD, Bradford J. Wood, MD, S. Nahum Goldberg, MD, W. Scott McDougal, MD and Peter R. Mueller, MD

1 From the Department of Radiology, Massachusetts General Hospital, Fruit St, Boston, MA 02114. From the 1999 RSNA scientific assembly. Received February 11, 2000; revision requested March 24; revision received May 1; accepted May 22. Address correspondence to D.A.G. (e-mail: dgervais@partners.org).

PURPOSE: To report the authors’ early experience with radio-frequency (RF) ablation of renal cell carcinoma.

MATERIALS AND METHODS: Twenty-four percutaneous RF ablation treatments for nine tumors were performed in eight patients with renal cell carcinoma. Indications included coexistent morbidity, previous surgery, or solitary kidney in patients with a life expectancy shorter than 10 years. Smaller (<=3-cm) peripheral lesions (n = 3) were treated with single electrodes. All but one of the larger (>3 cm) and/or central lesions (n = 6) were treated with cluster or multiple electrodes. Patients returned for a second treatment when follow-up imaging depicted tumor enhancement. Follow-up imaging was performed at 1 and 3 months and then at 6-month intervals, with a mean follow-up of 10.3 months. Seven patients were alive at least 6 months after their initial treatment.

RESULTS: All five exophytic tumors were free of enhancement. One of three central tumors was free of enhancement. One tumor had both central and exophytic components and was free of enhancement. Three tumors were 3 cm or smaller and free of enhancement. Of the six tumors larger than 3 cm, four were free of enhancement.

CONCLUSION: Percutaneous RF ablation is a promising treatment for select patients with renal cell carcinoma. The ultimate role of this modality will continue to evolve and warrants further study.

Index terms: Kidney, interventional procedures, 81.1269 • Kidney neoplasms, CT, 81.12111, 81.12112, 81.30 • Kidney neoplasms, MR, 81.12141, 81.12143, 81.30 • Radiofrequency (RF) ablation, 81.1269




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