HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Spalinger, J. Articles by Seidman, E. G. Search for Related Content PubMed PubMed Citation Articles by Spalinger, J. Articles by Seidman, E. G.

Doppler US in Patients with Crohn Disease: Vessel Density in the Diseased Bowel Reflects Disease Activity¹

¹ From the Division of Pediatric Gastroenterology and Nutrition, Departments of Pediatrics (J.S., G.M., D.H., M.D., E.G.S.) and Medical Imaging (H.P., M.C.M., J.D.), Hôpital Sainte-Justine, Université de Montréal, 3175 Côte-Sainte-Catherine, Montréal, Québec, Canada H3T 1C5. Received May 21, 1999; revision requested July 22; final revision received May 30, 2000; accepted June 28. Supported in part by the Crohn’s and Colitis Foundation of Canada. E.G.S. supported by a research scholarship award from the FRSQ. Address correspondence to H.P. (e-mail: hpatriquin@videotron.ca).

PURPOSE: To determine if neovascularization associated with Crohn disease, as detected with Doppler ultrasonography (US), reflects clinical disease activity.

MATERIALS AND METHODS: A devised measurement, vessel density, was estimated with color Doppler US. Patients with Crohn disease underwent clinical and laboratory assessment in which the Crohn disease activity index was measured; patients underwent abdominal US the same week. Color Doppler US was performed by using a 7.5–10.0- or 8.0–12.0-MHz transducer, the lowest possible pulse repetition frequency without aliasing, a low wall filter, and high Doppler gain settings. The length and thickness of the affected loops were measured, and the number of color Doppler signals per square centimeter in the bowel loop was counted. Pulsed Doppler US was used to confirm that the signals originated from arteries or veins and not from movement artifacts.

RESULTS: Ninety-two patients (aged 7–20 years; mean, 14.85 years; 44 female, 48 male) underwent 119 examinations; 85 were performed in patients with active disease. Affected loops were thicker (10.6 vs 4.6 mm; P < .001) and had a higher vessel density with disease (69 of 119 examinations) than during remission (two of 34 examinations; P < .001).

CONCLUSION: Vessel density in affected bowel loops, as estimated with Doppler US, and bowel wall thickness (>5 mm) reflect disease activity in patients with Crohn disease.

Index terms: Abdomen, US, 74.1298, 74.12983, 74.12989 • Blood vessels, US, 95.12983 • Crohn disease, 74.262 • Intestines, abnormalities, 74.262 • Ultrasound (US), Doppler studies, 74.12983 • Ultrasound (US), pulsed, 74.12984

This article has been cited by other articles:

				J. H. Chidlow Jr., D. Shukla, M. B. Grisham, and C. G. Kevil Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G5 - G18. [Abstract] [Full Text] [PDF]

				J. H. Chidlow Jr., W. Langston, J. J.M. Greer, D. Ostanin, M. Abdelbaqi, J. Houghton, A. Senthilkumar, D. Shukla, A. P. Mazar, M. B. Grisham, et al. Differential Angiogenic Regulation of Experimental Colitis Am. J. Pathol., December 1, 2006; 169(6): 2014 - 2030. [Abstract] [Full Text] [PDF]

				J F Colombel, C A Solem, W J Sandborn, F Booya, E V Loftus Jr, W S Harmsen, A R Zinsmeister, K D Bodily, and J G Fletcher Quantitative measurement and visual assessment of ileal Crohn's disease activity by computed tomography enterography: correlation with endoscopic severity and C reactive protein Gut, November 1, 2006; 55(11): 1561 - 1567. [Abstract] [Full Text] [PDF]

				S. Goebel, M. Huang, W. C. Davis, M. Jennings, T. J. Siahaan, J. S. Alexander, and C. G. Kevil VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G648 - G654. [Abstract] [Full Text] [PDF]

				T. Ripolles, M. J. Martinez, V. Morote, and J. Errando Appendiceal involvement in Crohn's disease: gray-scale sonography and color Doppler flow features. Am. J. Roentgenol., April 1, 2006; 186(4): 1071 - 1078. [Abstract] [Full Text] [PDF]

				E F Stange, S P L Travis, S Vermeire, C Beglinger, L Kupcinkas, K Geboes, A Barakauskiene, V Villanacci, A Von Herbay, B F Warren, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis Gut, March 1, 2006; 55(suppl_1): i1 - i15. [Full Text] [PDF]

				A. Sitek and R. G. Sheiman Small-Bowel Perfusion Measurement: Feasibility with Single-Compartment Kinetic Model Applied to Dynamic Contrast-enhanced CT Radiology, November 1, 2005; 237(2): 670 - 674. [Abstract] [Full Text] [PDF]

				R. Faingold, A. Daneman, G. Tomlinson, P. S. Babyn, D. E. Manson, A. Mohanta, A. M. Moore, J. Hellmann, C. Smith, T. Gerstle, et al. Necrotizing Enterocolitis: Assessment of Bowel Viability with Color Doppler US Radiology, May 1, 2005; 235(2): 587 - 594. [Abstract] [Full Text] [PDF]

				E M Danse, J Jamart, P Hoang, P F Laterre, A Kartheuser, and B E Van Beers Focal bowel wall changes detected with colour Doppler ultrasound: diagnostic value in acute non-diverticular diseases of the colon Br. J. Radiol., November 1, 2004; 77(923): 917 - 921. [Abstract] [Full Text] [PDF]

				S. S. Lee, H. K. Ha, S.-K. Yang, A. Y. Kim, T. K. Kim, P. N. Kim, M.-G. Lee, S.-J. Myung, H.-Y. Jung, J. H. Kim, et al. CT of Prominent Pericolic or Perienteric Vasculature in Patients with Crohn's Disease: Correlation with Clinical Disease Activity and Findings on Barium Studies Am. J. Roentgenol., October 1, 2002; 179(4): 1029 - 1036. [Abstract] [Full Text] [PDF]