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Captopril MR Renography in a Swine Model: Toward a Comprehensive Evaluation of Renal Arterial Stenosis¹

¹ From the Departments of Radiology (P.V.P., J.G., A.P., W.L., R.R.E.) and Surgery, (C.S.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass. From the 1998 RSNA scientific assembly. Received September 13, 1999; revision requested October 26; final revision received March 3, 2000; accepted March 13. P.V.P. supported in part by a grant-in-aid from the American Heart Association and National Institutes of Health grant R01 DK53221. R.R.E. supported in part by National Institutes of Health grant R01 DK48769-01A1. Address correspondence to P.V.P., Department of Radiology, MRI, Evanston Northwestern Healthcare, 2650 Ridge Ave, Evanston, IL 60201 (e-mail: pprasad@enh.org).

PURPOSE: To test the feasibility of captopril magnetic resonance (MR) renography and to validate the technique in an animal model of renal arterial stenosis.

MATERIALS AND METHODS: Seven pigs with induced renal arterial stenosis were studied. MR renography was performed with a T1-weighted approach by using three-dimensional fast imaging with steady-state precession, or FISP, sequences after administration of a bolus of 0.1 mmol of gadopentetate dimeglumine per kilogram of body weight. Captopril was administered to improve the specificity.

RESULTS: The results demonstrate that differences in renographic curves and indices are observed only if an anatomically substantial stenosis, typically a diameter reduction of more than 70%, is present and captopril is administered.

CONCLUSION: In this preliminary experience in an animal model, captopril MR renography provided data consistent with expectations based on conventional renographic results.

Index terms: Animals • Captopril, 961.12944 • Hypertension, renovascular, 961.723 • Magnetic resonance (MR), experimental studies, 961.12944 • Magnetic resonance (MR), phase-contrast imaging, 961.12944 • Magnetic resonance (MR), vascular studies, 961.12944 • Renal arteries, flow dynamics, 961.91 • Renal arteries, MR, 961.721 • Renal arteries, stenosis or obstruction, 961.721

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