HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moon, W. K. Articles by Park, I. A. Search for Related Content PubMed PubMed Citation Articles by Moon, W. K. Articles by Park, I. A.

US of Mammographically Detected Clustered Microcalcifications¹

¹ From the Departments of Radiology (W.K.M., J.G.I., Y.H.K.), Surgery (D.Y.N.), and Pathology (I.A.P.) and Clinical Research Institute, Seoul National University Hospital and the Institute of Radiation Medicine, SNUMRC, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea. Received December 22, 1999; revision requested January 25, 2000; revision received February 29; accepted March 24. Address correspondence to W.K.M. (e-mail: moonwk@radcom.snu.ac.kr).

PURPOSE: To determine whether ultrasonography (US) can depict breast masses associated with mammographically detected clustered microcalcifications and whether the visibility at US is different between benign and malignant lesions.

MATERIALS AND METHODS: Ninety-four patients with 100 mammographically detected microcalcification clusters prospectively underwent US with a 10- or 12-MHz transducer before mammographically guided presurgical hook-wire localization. The visibility of breast masses at US was correlated with histologic and mammographic findings.

RESULTS: Surgical biopsy revealed 62 benign lesions, 30 intraductal cancers, and eight invasive cancers. At US, breast masses associated with microcalcifications were seen in 45 (45%) of 100 cases. US depicted more breast masses associated with malignant (31 [82%] of 38) than with benign (14 [23%] of 62) microcalcifications (P < .001). In malignant microcalcification clusters larger than 10 mm, US depicted associated breast masses in all 25 cases. There was no statistically significant difference in shape and distribution of calcific particles, as well as in breast composition, at mammography between US visible and invisible groups.

CONCLUSION: Given a known mammographic location, US with a high-frequency transducer can depict breast masses associated with malignant microcalcifications, particularly clusters larger than 10 mm. US can be used to visualize large clusters of microcalcifications that have a very high suspicion of malignancy.

Index terms: Breast, US, 00.1298 • Breast neoplasms, calcifications, 00.3221, 00.3241 • Breast neoplasms, diagnosis, 00.1298, 00.301

This article has been cited by other articles:

				N. Cho and W. K. Moon Digital Mammography-Guided Skin Marking for Sonographically Guided Biopsy of Suspicious Microcalcifications Am. J. Roentgenol., March 1, 2009; 192(3): W132 - W136. [Abstract] [Full Text] [PDF]

				H. J. Shin, H. H. Kim, S. M. Kim, G. Y. Kwon, G. Gong, and O. K. Cho Screening-Detected and Symptomatic Ductal Carcinoma in Situ: Differences in the Sonographic and Pathologic Features Am. J. Roentgenol., February 1, 2008; 190(2): 516 - 525. [Abstract] [Full Text] [PDF]

				D. K. Kang, G. S. Jeon, H. Yim, and Y. S. Jung Diagnosis of the Intraductal Component of Invasive Breast Cancer: Assessment With Mammography and Sonography J. Ultrasound Med., November 1, 2007; 26(11): 1587 - 1600. [Abstract] [Full Text] [PDF]

				J. H. Youk, E.-K. Kim, M. J. Kim, J. Y. Lee, and K. K. Oh Missed Breast Cancers at US-guided Core Needle Biopsy: How to Reduce Them RadioGraphics, January 1, 2007; 27(1): 79 - 94. [Abstract] [Full Text] [PDF]

				J. H. Cha, W. K. Moon, N. Cho, S. M. Kim, S. H. Park, B.-K. Han, Y. H. Choe, J. M. Park, and J.-G. Im Characterization of Benign and Malignant Solid Breast Masses: Comparison of Conventional US and Tissue Harmonic Imaging Radiology, December 1, 2006; 242(1): 63 - 69. [Abstract] [Full Text] [PDF]

				J. H. Cha, W. K. Moon, N. Cho, S. Y. Chung, S. H. Park, J. M. Park, B. K. Han, Y. H. Choe, G. Cho, and J.-G. Im Differentiation of Benign from Malignant Solid Breast Masses: Conventional US versus Spatial Compound Imaging Radiology, December 1, 2005; 237(3): 841 - 846. [Abstract] [Full Text] [PDF]

				W. T. Yang and G. M. K. Tse Sonographic, Mammographic, and Histopathologic Correlation of Symptomatic Ductal Carcinoma In Situ Am. J. Roentgenol., January 1, 2004; 182(1): 101 - 110. [Abstract] [Full Text] [PDF]

				M. S. Soo, J. A. Baker, and E. L. Rosen Sonographic Detection and Sonographically Guided Biopsy of Breast Microcalcifications Am. J. Roentgenol., April 1, 2003; 180(4): 941 - 948. [Abstract] [Full Text] [PDF]

				W. K. Moon, D.-Y. Noh, and J.-G. Im Multifocal, Multicentric, and Contralateral Breast Cancers: Bilateral Whole-Breast US in the Preoperative Evaluation of Patients Radiology, August 1, 2002; 224(2): 569 - 576. [Abstract] [Full Text] [PDF]

				P. Vignal, M. R. Meslet, J. M. Romeo, and F. Feuilhade Sonographic Morphology of Infiltrating Breast Carcinoma: Relationship With the Shape of the Hyaluronan Extracellular Matrix J. Ultrasound Med., May 1, 2002; 21(5): 531 - 538. [Abstract] [Full Text] [PDF]

				M. S. Soo, J. A. Baker, E. L. Rosen, and T. T. Vo Sonographically Guided Biopsy of Suspicious Microcalcifications of the Breast: A Pilot Study Am. J. Roentgenol., April 1, 2002; 178(4): 1007 - 1015. [Abstract] [Full Text] [PDF]

				W. K. Moon, J. S. Myung, Y. J. Lee, I. A. Park, D.-Y. Noh, and J.-G. Im US of Ductal Carcinoma In Situ RadioGraphics, March 1, 2002; 22(2): 269 - 281. [Abstract] [Full Text] [PDF]