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Fiber Crossing in Human Brain Depicted with Diffusion Tensor MR Imaging¹

¹ From the Department of Radiology, Nuclear Magnetic Resonance Center, Massachusetts General Hospital-East, Bldg 149, 13th St, Charlestown, MA 02129 (M.R.W., V.J.W.); and the Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Denmark (M.R.W., H.B.W.L.). Received June 21, 1999; revision requested August 10; final revision received March 13, 2000; accepted March 20. Supported in part by the Sol Goldman Charitable Trust and National Institutes of Health grant 5RO1H256727. M.R.W supported by Apoteker fonden af 1991 (Copenhagen, Denmark). Address correspondence to V.J.W. (e-mail: van@nmr.mgh.harvard.edu).

Human white matter fiber crossings were investigated with use of the full eigenstructure of the magnetic resonance diffusion tensor. Intravoxel fiber dispersions were characterized by the plane spanned by the major and medium eigenvectors and depicted with three-dimensional graphics. This method improves the analysis of fiber orientations, beyond the principal fiber directions, to a broader range of complex fiber architectures.

Index terms: Brain, MR, 10.121411, 10.121416, 10.12146 • Brain, white matter, 10.87 • Magnetic resonance (MR), diffusion study, 10.121411, 10.121416, 10.12146, 10.87 • Magnetic resonance (MR), image display, 10.121411, 10.121416, 10.12146, 10.87 • Magnetic resonance (MR), tissue characterization, 10.121411, 10.121416, 10.12146, 10.87

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