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Cardiac Imaging |
1 From the Department of Epidemiology, University of Michigan, Ann Arbor (L.F.B., P.A.P.); and the Department of Diagnostic Radiology, Mayo Clinic and Foundation, 200 Second St SW, Rochester, MN 55905 (P.F.S.). Received February 7, 2000; revision requested April 3; revision received June 19; accepted July 14. Supported by National Institutes of Health grant R01 HL46292 and a General Clinical Research Center grant from the National Institutes of Health (MO1-RR00585) awarded to Mayo Clinic Rochester. Address correspondence to P.F.S. (e-mail: psheedy@mayo.edu).
PURPOSE: To use a recently described regression approach to evaluate agreement in the quantity of coronary artery calcification (CAC) with two consecutive acquisitions (dual scan runs) at electron-beam computed tomography (CT) in a quality-control program and to assess the change in CAC quantity over time in an individual.
MATERIALS AND METHODS: A total of 1,376 asymptomatic research participants, who were not selected because they were at high risk for coronary artery disease, were examined for the quantity of CAC with dual scan runs at electron-beam CT. With these data, 95% limits of agreement were established and used to evaluate differences between scan runs performed approximately 3.5 years apart in 81 participants.
RESULTS: The 95% limits of agreement depended on the mean quantity of CAC in the dual scan runs. Of the 81 participants whose examinations were approximately 3.5 years apart, 59 (73%) had no apparent change in CAC between the two examinations, 21 (26%) had large increases suggesting progression of CAC, and one (1%) had a large decrease suggesting regression of CAC.
CONCLUSION: The demonstrated method can be used to evaluate both agreement in dual scan runs and change in quantity of CAC over time.
Index terms: Computed tomography (CT), electron beam, 54.12111, 54.12119 • Coronary vessels, calcification, 54.81 • Coronary vessels, CT, 54.12111, 54.12119 • Statistical analysis
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