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(Radiology. 2001;218:261-266.)
© RSNA, 2001

Technical Developments

Quantitative Hemoglobin Tomography with Diffuse Near-Infrared Spectroscopy: Pilot Results in the Breast1

Brian W. Pogue, PhD, Steven P. Poplack, MD, Troy O. McBride, BS, Wendy A. Wells, MD, MSc, K. Sunshine Osterman, BS, Ulf L. Osterberg, PhD and Keith D. Paulsen, PhD

1 From the Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755-8000 (B.W.P., T.O.M., K.S.O., U.L.O., K.D.P.); and the Departments of Radiology (S.P.P.) and Pathology (W.A.W.), Dartmouth-Hitchcock Medical Center, Lebanon, NH. Received December 28, 1999; revision requested February 4, 2000; revision received April 1; accepted May 26. Supported by the National Institutes of Health through National Cancer Institute grants RO1CA69544 and P01CA80139. Address correspondence to K.D.P. (e-mail: keith.paulsen@dartmouth.edu).

The authors describe what is, to the best of their knowledge, the first quantitative hemoglobin concentration images of the female breast that were formed with model-based reconstruction of near-infrared intensity–modulated tomographic data. The results in 11 patients, including two with breast tumors with pathologic correlation, are summarized. Hemoglobin concentration appears to correlate with tumor vascularity without the need for exogenous contrast material and thereby has intrinsic diagnostic value.

Index terms: Breast neoplasms, 00.311, 00.324 • Breast neoplasms, radiography, 00.111, 00.112, 00.113 • Breast radiography, 00.111, 00.112, 00.113 • Breast radiography, technology, 00.111, 00.112, 00.113 • Infrared and near-infrared spectroscopy • Tomography, 00.19




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