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Gastrointestinal Imaging |
1 From the Departments of Diagnostic Radiology (J.T.H., A.B., N.I., H.J.W., K.J.K.) and Gastroenterology (D.M., M.K.), PU Marburg, University Hospital, Philipps University, Baldingerstrasse, 35033 Marburg, Germany; and the Center for Medical Diagnostic Systems and Visualization GmbH, University of Bremen, Germany (D.B.). Received March 3, 2000; revision requested April 25; revision received May 26; accepted June 28. Address correspondence to J.T.H. (e-mail: heverhag@post.med.uni-marburg.de).
PURPOSE: To evaluate magnetic resonance (MR) hydrometry, a method of quantifying fluid amounts by using MR imaging, for assessing the exocrine function of the pancreas after stimulation with secretin.
MATERIALS AND METHODS: Images were obtained with a single-shot turbo spin-echo sequence by using a 1.0-T magnet with a quadrature body coil. Image postprocessing and evaluation were performed at an external workstation by using a specially designed histogram algorithm that translates the MR signal intensity of duodenal filling into an actual amount of duodenal fluid. This algorithm was tested in vitro and in vivo. Finally, MR hydrometry results in five patients were correlated with those of the secretin-cerulein test.
RESULTS: The phantom measurements showed a high correlation (r = 0.99) between the actual amount of fluid in the imaging volume and the calculated results. In vivo, the ability of MR hydrometry to enable exact quantification of fluid amounts was demonstrated. In correlating the signal intensity of duodenal filling with the exact amount of additional fluid in the duodenum in volunteers, a coefficient of 0.043 gray tones per pixel per milliliter was calculated. The correlation (r) between secretin-stimulated duodenal fluid output estimated by using tube aspiration and that estimated by using MR hydrometry was 0.946 (P < .05).
CONCLUSION: MR hydrometry is a promising noninvasive method of assessing fluid output as a measure of exocrine pancreatic function.
Index terms: Magnetic resonance (MR), cholangiopancreatography, 78.121411, 78.121416, 78.12144 • Magnetic resonance (MR), comparative studies, 78.121411, 78.121416, 78.12144 • Magnetic resonance (MR), experimental studies, 78.121411, 78.121416, 78.12144 • Magnetic resonance (MR), volume measurement, 78.12144 • Pancreas, function, 770.91 • Pancreas, MR, 770.121411, 770.121416, 770.12144 • Secretin
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