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Early Changes in Liver Perfusion Caused by Occult Metastases in Rats: Detection with Quantitative CT¹

¹ From the Institut National de la Santé et de la Recherche Médicale (INSERM) U494, Paris, France (C.A.C., N.S., F.F., O.C., G.F.); and the Departments of Radiology (C.A.C., I.L., N.S., A.R., C.D., O.C., G.F.) and Pathology (B.P.), Hôpital European Georges Pompidou (HEGP), 20 rue Leblanc, 75015 Paris, France. From the 1998 RSNA scientific assembly. Received August 23, 1999; revision requested October 14; final revision received April 10, 2000; accepted April 21. Address correspondence to C.A.C. (e-mail: ca@cuenod.net).

PURPOSE: To determine whether computed tomography (CT) can depict liver hemodynamic changes caused by occult hepatic micrometastases in rat.

MATERIALS AND METHODS: Liver micrometastases (mean diameter, 500 µm ± 300) were produced in seven BD IX rats by injecting 10⁷ DHDK12 PROb colorectal carcinoma cells into the spleen. Macrometastases (mean diameter, 7 mm ± 3) were produced in four other rats. Five normal rats were studied as controls. CT images were obtained every 300 msec for 30 seconds during the injection of 1 mL per kilogram of body weight of contrast medium. The time-attenuation curves of the aorta, portal vein, and liver were used to calculate liver perfusion with a deconvolution model designed for the dual blood supply.

RESULTS: Micrometastases in an apparently normal liver caused a 34% decrease in portal blood flow and a 25% increase in the mean transit time for the blood to pass through the liver. These findings suggest increased resistance in the sinusoidal capillaries. Similar but greater changes were found in the macrometastases.

CONCLUSION: Occult liver micrometastases in rats generate changes in liver perfusion that can be detected with CT.

Index terms: Animals • Liver, blood supply • Liver, CT, 761.12111, 761.12113, 761.12115 • Liver neoplasms, metastases, 761.33

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