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(Radiology. 2001;218:598-601.)
© RSNA, 2001

Technical Developments

Clinically Relevant Rat Model for Testing BOLD Functional MR Imaging Techniques by Using Single-Shot Echo-planar Imaging at 1.5 T1

Douglas W. Morton, MD, PhD, Kenneth R. Maravilla, MD, Joseph R. Meno, PhD and H. Richard Winn, MD

1 From the Departments of Radiology (D.W.M., K.R.M.) and Neurological Surgery (K.R.M., J.R.M., H.R.W.), University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195. From the 1999 RSNA scientific assembly. Received December 30, 1999; revision requested February 28, 2000; revision received May 15; accepted June 1. D.W.M. supported by an RSNA Research Resident Grant from the RSNA Research and Education Foundation. Work also supported by National Institutes of Health grant NS21076. Address correspondence to D.W.M.

By using a 1.5-T whole-body magnetic resonance (MR) imager, a high-spatial-resolution single-shot echo-planar technique was developed to perform blood oxygen level dependent functional MR imaging of rat sensory cortex during forepaw stimulation. This technique produced cubic 1-mm3 voxels. Signal-to-noise ratio was 140–160 (43–44 dB). Optimal effective echo time was 50 msec. This system should prove useful for developing new functional MR imaging techniques with rapid adaptation to human use.

Index terms: Animals, 10.121412, 10.121415, 10.121416 • Brain, MR, 10.121412, 10.121415, 10.121416 • Experimental study, 10.121412, 10.121415, 10.121416 • Magnetic resonance (MR), echo planar, 10.121416 • Magnetic resonance (MR), functional imaging, 10.121412, 10.121415, 10.121416




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