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Experimental Studies |
1 From the Department of Radiology, Northwestern University Medical School, 448 E Ontario St, Ste 700, Chicago, IL 60611 (D.L., J.Z.); and Schering AG, Berlin, Germany (H.J.W.). Received April 8, 1999; revision requested June 15; final revision received July 19, 2000; accepted July 25. Supported in part by National Institutes of Health grant HL 38698 and research grants from Schering AG, Berlin, Germany; Berlex Laboratories, Wayne, NJ; and Siemens Medical Systems, Erlangen, Germany. Address correspondence to D.L. (e-mail: d-li2@northwestern.edu).
PURPOSE: To compare the efficacy of an intravascular contrast agent, gadomer-17, in improving magnetic resonance (MR) imaging of coronary arteries with that of an extravascular agent, gadopentetate dimeglumine, in pigs.
MATERIALS AND METHODS: Eight pigs underwent imaging after three injections: 0.20 mmol of gadopentetate dimeglumine per kilogram of body weight and 0.05 and 0.10 mmol/kg gadomer-17. Coronary images were acquired repeatedly after each injection by using an inversion-recovery–prepared segmented three-dimensional sequence with either breath holding (n = 4) or respiratory gating (n = 4). Coronary artery–to–myocardium contrast-to-noise ratios (CNRs) were compared between injections.
RESULTS: At breath-hold imaging, substantial CNR improvement over precontrast images was observed in images acquired during the first pass of gadopentetate dimeglumine in coronary arteries and up to 6 and 10 minutes after 0.05 and 0.10 mmol/kg of gadomer-17 injections, respectively. The CNR with 0.10 mmol/kg of gadomer-17 was 20% (P < .05) higher than that with gadopentetate dimeglumine at first-pass imaging. At respiratory-gated imaging, significant CNR improvement (P < .05) over precontrast images was observed in images acquired up to 10, 30, and 50 minutes after gadopentetate dimeglumine and both gadomer-17 injections, respectively. The CNR on the first images obtained after 0.10 mmol/kg gadomer-17 injection was 168% (P < .05) higher than that on the images obtained after gadopentetate dimeglumine injection.
CONCLUSION: Gadomer-17 provided greater and more persistent CNR improvements than did gadopentetate dimeglumine; further evaluation of its utility for coronary imaging in humans is warranted.
Index terms: Animals • Coronary vessels, MR, 54.121412, 54.121413, 54.12143, 54.12149 • Magnetic resonance (MR), contrast enhancement, 54.12143, 54.12149 • Magnetic resonance (MR), vascular studies, 54.12143, 54.12149
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