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Cardiac Imaging |
1 From the Cardiovascular Division, Barnes-Jewish Hospital at Washington University Medical Center, St Louis, Mo (S.J.F., S.E.F., C.H.L.); and Philips Medical Systems, Best, the Netherlands (S.E.F.). Received April 26, 2000; revision requested June 12; revision received June 28; accepted July 6. Supported in part by the Wolff Charitable Trust and Philips Medical Systems. S.J.F. supported by a grant from the Deutsche Forschungsgemeinschaft. Address correspondence to C.H.L., Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney St, London SW3 6NP, England (e-mail: chlorenz00@aol.com).
PURPOSE: To establish a method for measuring the partition coefficient (
) of gadopentetate dimeglumine in humans in vivo, evaluate the spatial and intersubject variation in the of normal myocardium, and compare these values on a regional basis with values of acute and chronic infarcted myocardium.
MATERIALS AND METHODS: Twelve healthy subjects and patients with acute (n = 5) or chronic (n = 5) myocardial infarction underwent magnetic resonance imaging at 1.5 T. Look-Locker images were acquired at four short-axis levels to measure myocardial and blood longitudinal relaxation time at baseline and after a 30–40-minute infusion of gadopentetate dimeglumine. was calculated as 
R1M/R1B, where M = myocardium, and B = blood.
RESULTS: The magnitude of the estimated in normal myocardium was uniform over the entire myocardium at 0.56 mL/g ± 0.10 (SD). The values in patients with acute (0.91 mL/g ± 0.11, P < .001) or chronic ( = 0.78 mL/g ± 0.09, P < .001) infarction were significantly elevated, as compared with those in healthy subjects. A 20% elevation in , as compared with the mean value of a corresponding normal circumferential segment, allowed identification of chronically (sensitivity, 88%; specificity, 96%) or acutely (sensitivity, 100%; specificity, 98%) infarcted segments.
CONCLUSION: Quantification of the in vivo allows differentiation between normal and acutely or chronically infarcted myocardium, with high sensitivity and specificity.
Index terms: Magnetic resonance (MR), contrast enhancement, 51.121412, 51.12143 • Myocardium, infarction, 511.771 • Myocardium, MR, 511.121412, 511.12143
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