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(Radiology. 2001;219:153-156.)
© RSNA, 2001

Experimental Studies

Comparison of Three Mechanical Thrombus Removal Devices in Thrombosed Canine Iliac Arteries1

Flavio Castañeda, MD, Ruizong Li, MD, Jitendra Patel, MD, James R. DeBord, MD and James L. Swischuk, MD

1 From the Departments of Radiology (F.C., R.L., J.L.S.), Pathology (J.P.), and Surgery (J.R.D.), University of Illinois College of Medicine at Peoria, 1 Illini Dr, PO Box 1649, Peoria, IL 61656. Received March 16, 2000; revision requested May 2; revision received August 14; accepted September 12. Address correspondence to F.C. (e-mail: fcastaneda@peorad.com).

PURPOSE: To assess and compare intimal and medial vascular damage caused by three mechanical wall-contact thrombectomy devices: Fogarty embolectomy catheter, Arrow-Trerotola peripheral thrombectomy device, and MTI-Castañeda over-the-wire brush.

MATERIALS AND METHODS: Bilateral external iliac arteries of 15 canines were thrombosed before mechanical thrombolysis. Ten thrombosed arteries were randomly assigned to receive each device. Animals were sacrificed immediately, and histologic assessment of endothelial and medial damage in the vessels was performed.

RESULTS: The vascular damage found with all devices extended into the tunica media. The Fogarty embolectomy catheter and the Arrow-Trerotola device caused significantly more damage than the Castañeda brush.

CONCLUSION: All devices caused lesions extending into the media. Previous research has shown that the extent and depth of the vascular lesion may be contributing factors in promoting early atherosclerotic and accelerated hyperplastic intimal and medial changes. These findings warrant further study of these devices in an atherosclerotic model with longer follow-up.

Index terms: Animals • Arteries, iliac, 986.442 • Arteries, thrombosis, 986.442 • Thrombolysis, 986.1269 • Thrombosis, experimental studies, 986.1269