Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldberg, S. N.
Right arrow Articles by Lenkinski, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldberg, S. N.
Right arrow Articles by Lenkinski, R. E.
(Radiology. 2001;219:157-165.)
© RSNA, 2001

Experimental Studies

Radio-Frequency Thermal Ablation with NaCl Solution Injection: Effect of Electrical Conductivity on Tissue Heating and Coagulation—Phantom and Porcine Liver Study1

S. Nahum Goldberg, MD, Muneeb Ahmed, MD, G. Scott Gazelle, MD, PhD, Jonathan B. Kruskal, MD, PhD, Juan Carlos Huertas, MD, Elkan F. Halpern, PhD, Brian S. Oliver, BSc and Robert E. Lenkinski, PhD

1 From the Departments of Radiology of Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215 (S.N.G., M.A., J.B.K., J.C.H., B.S.O., R.E.L.); and Massachusetts General Hospital, Boston (G.S.G., E.F.H.). Received May 11, 2000; revision requested July 7; revision received August 4; accepted August 30. Supported in part by grants from Radionics, Burlington, Mass. Address correspondence to S.N.G. (e-mail: sgoldber@caregroup.harvard.edu).

PURPOSE: To characterize the effects of NaCl concentration on tissue electrical conductivity, radio-frequency (RF) deposition, and heating in phantoms and optimize adjunctive NaCl solution injection for RF ablation in an in vivo model.

MATERIALS AND METHODS: RF was applied for 12–15 minutes with internally cooled electrodes. For phantom experiments (n = 51), the NaCl concentration in standardized 5% agar was varied (0%–25.0%). A nonlinear simplex optimization strategy was then used in normal porcine liver (n = 44) to determine optimal pre-RF NaCl solution injection parameters (concentration, 0%–38.5%; volume, 0–25 mL). NaCl concentration and tissue conductivity were correlated with RF energy deposition, tissue heating, and induced coagulation.

RESULTS: NaCl concentration had significant but nonlinear effects on electrical conductivity, RF deposition, and heating of agar phantoms (P < .01). Progressively greater heating was observed to 5.0% NaCl, with reduced temperatures at higher concentrations. For in vivo liver, NaCl solution volume and concentration significantly influenced both tissue heating and coagulation (P < .001). Maximum heating 20 mm from the electrode (102.9°C ± 4.3 [SD]) and coagulation (7.1 cm ± 1.1) occurred with injection of 6 mL of 38.5% (saturated) NaCl solution.

CONCLUSION: Injection of NaCl solution before RF ablation can increase energy deposition, tissue heating, and induced coagulation, which will likely benefit clinical RF ablation. In normal well-perfused liver, maximum coagulation (7.0 cm) occurs with injection of small volumes of saturated NaCl solution.

Index terms: Liver, interventional procedures • Liver neoplasms, therapy, 761.1289, 761.30 • Radiofrequency (RF) ablation




This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
S. Mulier, Y. Ni, L. Frich, F. Burdio, A. L. Denys, J.-F. De Wispelaere, B. Dupas, N. Habib, M. Hoey, M. C. Jansen, et al.
Experimental and Clinical Radiofrequency Ablation: Proposal for Standardized Description of Coagulation Size and Geometry
Ann. Surg. Oncol., April 1, 2007; 14(4): 1381 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
P-Y Marcy, N Magne, P Castadot, C Bailet, and M Namer
Ultrasound-guided percutaneous radiofrequency ablation in elderly breast cancer patients: preliminary institutional experience
Br. J. Radiol., April 1, 2007; 80(952): 267 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
X. Buy, A. Basile, G. Bierry, J. Cupelli, and A. Gangi
Saline-infused bipolar radiofrequency ablation of high-risk spinal and paraspinal neoplasms.
Am. J. Roentgenol., May 1, 2006; 186(5 Suppl): S322 - S326.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. U. Hines-Peralta, N. Pirani, P. Clegg, N. Cronin, T. P. Ryan, Z. Liu, and S. N. Goldberg
Microwave Ablation: Results with a 2.45-GHz Applicator in ex Vivo Bovine and in Vivo Porcine Liver
Radiology, April 1, 2006; 239(1): 94 - 102.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. R. Haaga, A. A. Exner, Y. Wang, N. T. Stowe, and P. J. Tarcha
Combined Tumor Therapy by Using Radiofrequency Ablation and 5-FU-Laden Polymer Implants: Evaluation in Rats and Rabbits
Radiology, December 1, 2005; 237(3): 911 - 918.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
B. B. Frericks, J. P. Ritz, A. Roggan, K.-J. Wolf, and T. Albrecht
Multipolar Radiofrequency Ablation of Hepatic Tumors: Initial Experience
Radiology, December 1, 2005; 237(3): 1056 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. A. Solazzo, Z. Liu, S. M. Lobo, M. Ahmed, A. U. Hines-Peralta, R. E. Lenkinski, and S. N. Goldberg
Radiofrequency Ablation: Importance of Background Tissue Electrical Conductivity--An Agar Phantom and Computer Modeling Study
Radiology, August 1, 2005; 236(2): 495 - 502.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. de Baere, C. Dromain, M. Lapeyre, P. Briggs, J. S. Duret, A. Hakime, V. Boige, and M. Ducreux
Artificially Induced Pneumothorax for Percutaneous Transthoracic Radiofrequency Ablation of Tumors in the Hepatic Dome: Initial Experience
Radiology, August 1, 2005; 236(2): 666 - 670.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee Jr
Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model
Radiology, July 1, 2005; 236(1): 132 - 139.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. N. Goldberg, C. J. Grassi, J. F. Cardella, J. W. Charboneau, G. D. Dodd II, D. E. Dupuy, D. Gervais, A. R. Gillams, R. A. Kane, F. T. Lee Jr, et al.
Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria
Radiology, June 1, 2005; 235(3): 728 - 739.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Ahmed, Z. Liu, A. N. Lukyanov, S. Signoretti, C. Horkan, W. L. Monsky, V. P. Torchilin, and S. N. Goldberg
Combination Radiofrequency Ablation with Intratumoral Liposomal Doxorubicin: Effect on Drug Accumulation and Coagulation in Multiple Tissues and Tumor Types in Animals
Radiology, May 1, 2005; 235(2): 469 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
Z. Liu, S. M. Lobo, S. Humphries, C. Horkan, S. A. Solazzo, A. U. Hines-Peralta, R. E. Lenkinski, and S. N. Goldberg
Radiofrequency Tumor Ablation: Insight into Improved Efficacy Using Computer Modeling
Am. J. Roentgenol., April 1, 2005; 184(4): 1347 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. M. Lee, J. K. Han, S. H. Choi, S. H. Kim, J. Y. Lee, K. S. Shin, C. J. Han, and B. I. Choi
Comparison of Renal Ablation with Monopolar Radiofrequency and Hypertonic-Saline-Augmented Bipolar Radiofrequency: In Vitro and In Vivo Experimental Studies
Am. J. Roentgenol., March 1, 2005; 184(3): 897 - 905.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
P. F. Laeseke, L. A. Sampson, T. C. Winter III, and F. T. Lee Jr.
Use of Dextrose 5% in Water Instead of Saline to Protect Against Inadvertent Radiofrequency Injuries
Am. J. Roentgenol., March 1, 2005; 184(3): 1026 - 1027.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. M. Lee, J. K. Han, S. H. Kim, S. H. Choi, S. K. An, C. J. Han, and B. I. Choi
Bipolar Radiofrequency Ablation Using Wet-Cooled Electrodes: An In Vitro Experimental Study in Bovine Liver
Am. J. Roentgenol., February 1, 2005; 184(2): 391 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
J M Lee, J K Han, S H Kim, J Y Lee, S H Choi, and B I Choi
Hepatic bipolar radiofrequency ablation using perfused-cooled electrodes: a comparative study in the ex vivo bovine liver
Br. J. Radiol., November 1, 2004; 77(923): 944 - 949.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
A R Gillams
Liver ablation therapy
Br. J. Radiol., September 1, 2004; 77(921): 713 - 723.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. Lieberman, E. Goldin, M. Lotem, and A. I. Bloom
Irrigation of the Bile Ducts with Chilled Saline During Percutaneous Radiofrequency Ablation of a Hepatic Ocular Melanoma Metastasis
Am. J. Roentgenol., September 1, 2004; 183(3): 596 - 598.
[Full Text] [PDF]

Home page
 RadiologyHome page
S. A. Shock, K. Meredith, T. F. Warner, L. A. Sampson, A. S. Wright, T. C. Winter III, D. M. Mahvi, J. P. Fine, and F. T. Lee Jr
Microwave Ablation with Loop Antenna: In Vivo Porcine Liver Model
Radiology, April 1, 2004; 231(1): 143 - 149.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Ahmed, Z. Liu, K. S. Afzal, D. Weeks, S. M. Lobo, J. B. Kruskal, R. E. Lenkinski, and S. N. Goldberg
Radiofrequency Ablation: Effect of Surrounding Tissue Composition on Coagulation Necrosis in a Canine Tumor Model
Radiology, March 1, 2004; 230(3): 761 - 767.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. M. Lobo, K. S. Afzal, M. Ahmed, J. B. Kruskal, R. E. Lenkinski, and S. N. Goldberg
Radiofrequency Ablation: Modeling the Enhanced Temperature Response to Adjuvant NaCl Pretreatment
Radiology, January 1, 2004; 230(1): 175 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. A. Farrell, J. W. Charboneau, M. R. Callstrom, C. C. Reading, D. E. Engen, and M. L. Blute
Paranephric Water Instillation: A Technique to Prevent Bowel Injury During Percutaneous Renal Radiofrequency Ablation
Am. J. Roentgenol., November 1, 2003; 181(5): 1315 - 1317.
[Full Text] [PDF]

Home page
 RadiologyHome page
F. Burdio, A. Guemes, J. M. Burdio, A. Navarro, R. Sousa, T. Castiella, I. Cruz, O. Burzaco, and R. Lozano
Bipolar Saline-enhanced Electrode for Radiofrequency Ablation: Results of Experimental Study of in Vivo Porcine Liver
Radiology, November 1, 2003; 229(2): 447 - 456.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Ahmed, W. E. Monsky, G. Girnun, A. Lukyanov, G. D'Ippolito, J. B. Kruskal, K. E. Stuart, V. P. Torchilin, and S. N. Goldberg
Radiofrequency Thermal Ablation Sharply Increases Intratumoral Liposomal Doxorubicin Accumulation and Tumor Coagulation
Cancer Res., October 1, 2003; 63(19): 6327 - 6333.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. N. Goldberg, J. W. Charboneau, G. D. Dodd III, D. E. Dupuy, D. A. Gervais, A. R. Gillams, R. A. Kane, F. T. Lee Jr, T. Livraghi, J. P. McGahan, et al.
Image-guided Tumor Ablation: Proposal for Standardization of Terms and Reporting Criteria
Radiology, August 1, 2003; 228(2): 335 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. Kettenbach, W. Kostler, E. Rucklinger, B. Gustorff, M. Hupfl, F. Wolf, K. Peer, M. Weigner, J. Lammer, W. Muller, et al.
Percutaneous Saline-Enhanced Radiofrequency Ablation of Unresectable Hepatic Tumors: Initial Experience in 26 Patients
Am. J. Roentgenol., June 1, 2003; 180(6): 1537 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D. Schmidt, J. Trubenbach, J. Brieger, C. Koenig, H. Putzhammer, S. H. Duda, C. D. Claussen, and P. L. Pereira
Automated Saline-Enhanced Radiofrequency Thermal Ablation: Initial Results in Ex Vivo Bovine Livers
Am. J. Roentgenol., January 1, 2003; 180(1): 163 - 165.
[Full Text] [PDF]

Home page
 RadiologyHome page
W. L. Monsky, J. B. Kruskal, A. N. Lukyanov, G. D. Girnun, M. Ahmed, G. S. Gazelle, J. C. Huertas, K. E. Stuart, V. P. Torchilin, and S. N. Goldberg
Radio-frequency Ablation Increases Intratumoral Liposomal Doxorubicin Accumulation in a Rat Breast Tumor Model
Radiology, September 1, 2002; 224(3): 823 - 829.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. N. Goldberg, I. R. Kamel, J. B. Kruskal, K. Reynolds, W. L. Monsky, K. E. Stuart, M. Ahmed, and V. Raptopoulos
Radiofrequency Ablation of Hepatic Tumors: Increased Tumor Destruction with Adjuvant Liposomal Doxorubicin Therapy
Am. J. Roentgenol., July 1, 2002; 179(1): 93 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D. S. K. Lu, S. S. Raman, D. J. Vodopich, M. Wang, J. Sayre, and C. Lassman
Effect of Vessel Size on Creation of Hepatic Radiofrequency Lesions in Pigs: Assessment of the "Heat Sink" Effect
Am. J. Roentgenol., January 1, 2002; 178(1): 47 - 51.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
H. Rhim, S. N. Goldberg, G. D. Dodd III, L. Solbiati, H. K. Lim, M. Tonolini, and O. K. Cho
Essential Techniques for Successful Radio-frequency Thermal Ablation of Malignant Hepatic Tumors
RadioGraphics, October 1, 2001; 21(90001): S17 - 35.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. Boehm, A. Malich, S. N. Goldberg, J. R. Reichenbach, I. Hilger, P. Hauff, M. Reinhardt, M. Fleck, and W. A. Kaiser
Radio-frequency Tumor Ablation: Internally Cooled Electrode versus Saline-enhanced Technique in an Aggressive Rabbit Tumor Model
Radiology, March 1, 2002; 222(3): 805 - 813.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2001 by the Radiological Society of North America.