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Renal Blood Flow Changes Induced with Endothelin-1 and Fenoldopam Mesylate at Quantitative Doppler US: Initial Results in a Canine Study¹

¹ From the Department of Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104-6086 (C.M.S., P.H.A., J.A.P., H.M.S.); and SmithKline Beecham, King of Prussia, Pa (A.C.S., A.B., C.P.B.). Received March 9, 2000; revision requested April 25; revision received October 24; accepted November 14. Address correspondence to C.M.S. (e-mail: sehgal@oasis.rad.upenn .edu).

PURPOSE: To evaluate quantitative Doppler ultrasonography (US) for assessing renal blood flow changes induced with endothelin-1 (ET-1) and fenoldopam mesylate in conscious dogs.

MATERIALS AND METHODS: A blood flow probe was surgically implanted around the renal artery in eight adult dogs. Color and power Doppler US images were acquired in conscious restrained dogs during intravenous infusion of ET-1 and fenoldopam mesylate. Simultaneous with imaging, blood flow through the renal artery was measured with the implanted probe. The color level of the images within the region representing the kidney was analyzed to derive flow indices. These indices were compared with direct-flow measurements.

RESULTS: The flow indices, color-weighted flow area (CWFA), and percentage of area of color, derived from color and power Doppler US images, correlated linearly with direct flow. The mean color level of color and power Doppler US images correlated weakly with direct flow. Pre- versus postinfusion CWFA decreased with all ET-1 infusions (P .032). Infusion of fenoldopam mesylate increased CWFA in all cases (P .032).

CONCLUSION: Quantitative Doppler US enabled successful measurement of the flow changes induced with ET-1 and fenoldopam mesylate. Quantitative Doppler US is potentially useful as a noninvasive surrogate endpoint in evaluating the action of various therapeutic agents.

Index terms: Kidney, blood supply, 81.12981, 81.12982, 81.12983, 81.12984 • Kidney, perfusion, 81.12981, 81.12982, 81.12983, 81.12984 • Kidney, US, 81.12981, 81.12982, 81.12983, 81.12984 • Ultrasound (US), experimental studies, 81.12981, 81.12982, 81.12983, 81.12984

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