Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murphy, K. J.
Right arrow Articles by Rüfenacht, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, K. J.
Right arrow Articles by Rüfenacht, D. A.
(Radiology. 2001;219:541-544.)
© RSNA, 2001

Vascular and Interventional Radiology

Mechanical Detachable Platinum Coil: Report of the European Phase II Clinical Trial in 60 Patients1

Kieran J. Murphy, MD, FRCPC, Emmanuel Houdart, MD, Kazimierz T. Szopinski, MD, PhD, Olivier Levrier, MD, Leopoldo Guimaraens, MD, Dietmar Kühne, MD, László Solymosi, MD, Niels J. Bartholdy, MD and Daniel A. Rüfenacht, MD

1 From the Div of Diagnostic and Interventional Radiology, Geneva Univ Hospital, Switzerland (K.J.M., D.A.R.); Dept of Radiology, Johns Hopkins School of Medicine, B-100, 600 N Wolfe St, Baltimore, MD 21287 (K.J.M., K.T.S.); Dept of Neuroradiology and Therapeutic Angiography, Hôpital Lariboisière, Paris, France (E.H.); Dept of Neuroradiology and Vascular Radiology, Hôpital d’Adultes de la Timone, Marseilles, France (O.L.); Dept of Diagnostic and Therapeutic Neuroangiography, Hospital General de Cataluña, Barcelona, Spain (L.G.); Dept of Radiology and Neuroradiology, Alfried-Krupp-Krankenhaus, Essen, Germany (D.K.); Dept of Neuroradiology, Bayerische Julius-Maximilians Universität, Würzburg, Germany (L.S.); and Dept of Radiology, Ålborg Sygehus Syd, Denmark (N.J.B.). From the 1999 RSNA scientific assembly. Received Mar 24, 2000; revision requested May 25; revision received Aug 23; accepted Sep 11. Address correspondence to K.J.M. (e-mail: kmurphy@jhmi.edu).

PURPOSE: To determine the safety and reliability of the mechanical detachment system of a platinum coil (Detach-18) when used for neurovascular embolization.

MATERIALS AND METHODS: Sixty patients (21 men, 39 women; age range, 26–75 years; mean age, 56.2 years) were treated in seven centers. Ease of introduction of the coil to the microcatheter, effect of coil passage on the microcatheter shape and stability during its delivery, retrievability of the coil before and after the transition zone passed beyond the microcatheter, detachment of the coil, and effect of coil rotation on the microcatheter stability were evaluated. The detachment system itself was evaluated for premature detachment, failure of the coil to detach, detachment time, number of turns, visibility of radiopaque markers, number of coils deployed per patient, and percentage of vessel occlusion obtained. A 0.015-inch-diameter regular coil and a 0.014-inch-diameter soft coil were used.

RESULTS: A total of 1,061 coils were used; 1,009 were detached. The number of coils deployed ranged from four to 104 (mean, 17 coils). The coils passed easily through the microcatheter. The detachment maneuver occurred within 5–25 seconds, with five to 60 turns of the introducing wire. One premature coil detachment occurred without clinical sequela; 100% occlusion of the vessel lumen was achieved in 53 patients; 80%–90%, in four; and 70%–80%, in two. There were no device-related complications.

CONCLUSION: The detachment system was safe and reliable. This is a useful system for coil embolization in neurovascular diseases.

Index terms: Aneurysm, intracranial, 17.73 • Cerebral blood vessels, therapeutic embolization, 17.1264 • Fistula, arteriovenous, 17.75 • Interventional procedures, technology, 17.1264