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Vertebral Bone Marrow Perfusion Evaluated with Dynamic Contrast-enhanced MR Imaging: Significance of Aging and Sex¹

¹ From the Department of Radiology, Taipei Municipal Jen-Ai Hospital, Taipei, Taiwan (W.T.C., R.C.C., C.T.C., J.M.L., H.Y.T.); the Department of Radiology, National Taiwan University, Medical College and Hospital, No. 7 Chung-Shan S Rd, Taipei 100, Taiwan (T.T.F.S.); and the Department of Radiology, Taipei Municipal Chun-Shau Hospital, Taipei, Taiwan (S.Y.L.). Received September 29, 2000; revision requested November 14; final revision received January 29, 2001; accepted February 26. Address correspondence to T.T.F.S. (e-mail: ttfshih@ha.mc.ntu.edu.tw).

PURPOSE: To investigate blood perfusion of nonfractured, normal-appearing vertebral bodies with regard to age and sex.

MATERIALS AND METHODS: Dynamic magnetic resonance imaging (160 images obtained in 80 seconds) was performed from T10 to L5 in 66 patients. Patients were assigned to three groups: group 1, those 50 years or younger without compression fracture; group 2, those older than 50 years without compression fracture; or group 3, those older than 50 years with compression fracture. Peak enhancement percentage and enhancement slope were determined from the time-intensity curve of normal (nonfractured) vertebral body. Comparisons were made between groups, and the effect of age and sex interaction was analyzed.

RESULTS: Higher peak enhancement percentage was demonstrated for group 1 compared with group 2 (58.21 ± 44.65 [SD] vs 21.88 ± 14.77, P < .005). Group 1 women revealed a higher enhancement percentage compared with group 1 men (87.17 ± 54.13 vs 38.16 ± 21.69, P < .05), which significantly decreased in those older than 50 years (from 87.17 ± 54.13 to 17.98 ± 13.80, P < .005). For men, this decrease in those older than 50 years was not as pronounced (from 38.16 ± 21.69 to 25.38 ± 15.43, P > .05). Presence of compression fracture at other levels of the spine (group 3) was not associated with a different enhancement percentage for normal vertebrae.

CONCLUSION: Rate of vertebral bone marrow perfusion revealed a significant decrease in subjects older than 50 years. Women demonstrated a higher marrow perfusion rate than men younger than 50 years and a more marked decrease than men older than 50 years.

Index terms: Aging • Bone marrow, 321.10, 331.10 • Bone marrow, MR, 321.12144, 331.12144 • Magnetic resonance (MR), contrast enhancement, 321.12143, 331.12143 • Magnetic resonance (MR), perfusion study, 321.12144, 331.12144 • Osteoporosis, 30.562 • Spine, 30.562

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