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Metacarpophalangeal Joints in Rheumatoid Arthritis: Laser Doppler Imaging—Initial Experience¹

¹ From the Centre for Rheumatic Diseases, University Department of Medicine, Royal Infirmary, Queen Elizabeth Bldg, 10 Alexandra Parade, Glasgow G31 2ER, Scotland (W.R.F., P.V.B., R.D.S.); and the Department of Biological Sciences, University of Paisley, Scotland (C.G.E., J.C.L.). Received August 18, 2000; revision requested September 26; revision received November 13; accepted January 9, 2001. Supported by Integrated Clinical Arthritis Centre award S0590 from the Arthritis Research Campaign. Address correspondence to W.R.F. (e-mail: w.ferrell@bio.gla.ac.uk).

Laser Doppler imaging is a noninvasive method yielding a spatial perfusion map. With use of a near-infrared laser, elevated perfusion associated with the metacarpophalangeal joints was detectable in patients with active rheumatoid arthritis. Findings at laser Doppler imaging correlated with pain scores and synovitis detected at ultrasonography, whereas the power Doppler sign (red pixels inside the active green box) did not. Laser Doppler imaging has the potential to help assess soft-tissue inflammation.

Index terms: Arthritis, rheumatoid, 437.71 • Extremities, 437.71 • Fingers and toes, 437.71 • Hand, 437.71 • Lasers, 437.12984 • Lasers, Doppler study, 437.1299 • Ultrasound (US), power Doppler studies, 437.12984

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