HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ding, H. Articles by Maekawa, K. Search for Related Content PubMed PubMed Citation Articles by Ding, H. Articles by Maekawa, K.

Hepatocellular Carcinoma: Depiction of Tumor Parenchymal Flow with Intermittent Harmonic Power Doppler US during the Early Arterial Phase in Dual-Display Mode¹

¹ From the Department of Gastroenterology and Hepatology (H.D., M.K., H.O., Y.S., Y.M.) and Section of Abdominal Ultrasound (K.M.), Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. Received June 12, 2000; revision requested July 24; final revision received February 15, 2001; accepted February 26. Address correspondence to M.K. (e-mail: m-kudo@med.kindai.ac.jp).

PURPOSE: To assess the effectiveness of contrast material–enhanced intermittent harmonic Doppler ultrasonography (US) in depicting tumor vessels and tumor parenchymal flow (stain) in hepatocellular carcinoma (HCC).

MATERIALS AND METHODS: Fifty-eight patients with 65 HCC nodules were examined by using intermittent harmonic power Doppler US and digital subtraction harmonic B-mode US, both with intravenous administration of SH U 508A. Vascular findings at early arterial phase harmonic US were classified as positive enhancement or nonenhancement, depending on the tumor vascularity relative to the surrounding liver parenchyma. These results were compared with those of three-phase helical dynamic computed tomography (CT).

RESULTS: For hypervascular HCCs, there was excellent depiction of tumor vessels and tumor stain with the two intermittent harmonic US methods. The sensitivity and specificity for depiction of tumor vascularity were 93% (41 of 44 nodules) and 100% (21 of 21), respectively, with intermittent harmonic power Doppler US and 86% (38 of 44) and 100% (21 of 21), respectively, with subtraction US, as compared with these values at dynamic CT. Attenuation was an important factor in the depictability of tumor vascularity at harmonic US.

CONCLUSION: Contrast-enhanced intermittent harmonic US enables noninvasive demonstration of tumor vessels and especially tumor stain in HCC.

Index terms: Liver neoplasms, 761.323 • Liver neoplasms, US, 761.12981, 761.12983, 761.12984, 761.12988 • Ultrasound (US), contrast media • Ultrasound (US), harmonic study, 761.12981, 761.12983, 761.12984, 761.12988

This article has been cited by other articles:

				T Hamada, M Yamauchi, M Tanaka, Y Hashimoto, K Nakai, and K Suenaga Prospective evaluation of contrast-enhanced ultrasonography with advanced dynamic flow for the diagnosis of intestinal ischaemia Br. J. Radiol., August 1, 2007; 80(956): 603 - 608. [Abstract] [Full Text] [PDF]

				Y. Minami, M. Kudo, H. Chung, T. Kawasaki, Y. Yagyu, T. Shimono, and H. Shiozaki Contrast Harmonic Sonography-Guided Radiofrequency Ablation Therapy Versus B-Mode Sonography in Hepatocellular Carcinoma: Prospective Randomized Controlled Trial Am. J. Roentgenol., February 1, 2007; 188(2): 489 - 494. [Abstract] [Full Text] [PDF]

				K. Takayasu, Y. Muramatsu, Y. Mizuguchi, T. Okusaka, K. Shimada, T. Takayama, and M. Sakamoto CT Evaluation of the progression of hypoattenuating nodular lesions in virus-related chronic liver disease. Am. J. Roentgenol., August 1, 2006; 187(2): 454 - 463. [Abstract] [Full Text] [PDF]

				H. Ding, W.-P. Wang, B.-J. Huang, R.-X. Wei, N.-A. He, Q. Qi, and C.-L. Li Imaging of Focal Liver Lesions: Low-Mechanical-Index Real-time Ultrasonography With SonoVue J. Ultrasound Med., March 1, 2005; 24(3): 285 - 297. [Abstract] [Full Text] [PDF]

				O. Catalano, A. Nunziata, R. Lobianco, and A. Siani Real-Time Harmonic Contrast Material-specific US of Focal Liver Lesions RadioGraphics, March 1, 2005; 25(2): 333 - 349. [Abstract] [Full Text] [PDF]

				Y. Minami, M. Kudo, T. Kawasaki, H. Chung, C. Ogawa, and H. Shiozaki Treatment of Hepatocellular Carcinoma with Percutaneous Radiofrequency Ablation: Usefulness of Contrast Harmonic Sonography for Lesions Poorly Defined with B-Mode Sonography Am. J. Roentgenol., July 1, 2004; 183(1): 153 - 156. [Abstract] [Full Text] [PDF]

				M Kitano, M Kudo, K Maekawa, Y Suetomi, H Sakamoto, N Fukuta, R Nakaoka, and T Kawasaki Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography Gut, June 1, 2004; 53(6): 854 - 859. [Abstract] [Full Text] [PDF]

				V. Migaleddu, G. Virgilio, D. Turilli, M. Conti, G. Campisi, N. Canu, D. Sirigu, and I. Vincentelli Characterization of Focal Liver Lesions in Real Time Using Harmonic Imaging with High Mechanical Index and Contrast Agent Levovist Am. J. Roentgenol., June 1, 2004; 182(6): 1505 - 1512. [Abstract] [Full Text] [PDF]

				Y. L. Wen, M. Kudo, R. Q. Zheng, H. Ding, P. Zhou, Y. Minami, H. Chung, M. Kitano, T. Kawasaki, and K. Maekawa Characterization of Hepatic Tumors: Value of Contrast-Enhanced Coded Phase-Inversion Harmonic Angio Am. J. Roentgenol., April 1, 2004; 182(4): 1019 - 1026. [Abstract] [Full Text] [PDF]

				K. W. Kim, B. I. Choi, S. H. Park, H.-C. Kim, M. W. Lee, S. H. Kim, K. H. Lee, C. H. Park, J. S. Kim, H.-J. Won, et al. Hepatocellular Carcinoma: Assessment of Vascularity With Single-Level Dynamic Ultrasonography During the Arterial Phase J. Ultrasound Med., September 1, 2003; 22(9): 887 - 896. [Abstract] [Full Text] [PDF]

				J. H. Youk, J. M. Lee, and C. S. Kim Therapeutic Response Evaluation of Malignant Hepatic Masses Treated by Interventional Procedures With Contrast-Enhanced Agent Detection Imaging J. Ultrasound Med., September 1, 2003; 22(9): 911 - 920. [Abstract] [Full Text] [PDF]

				Y. Minami, M. Kudo, T. Kawasaki, M. Kitano, H. Chung, K. Maekawa, and H. Shiozaki Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma: Usefulness of Coded Phase-Inversion Harmonic Sonography Am. J. Roentgenol., March 1, 2003; 180(3): 703 - 708. [Abstract] [Full Text] [PDF]

				K. Numata, T. Isozaki, Y. Ozawa, T. Sakaguchi, T. Kiba, T. Kubota, A. Ito, K. Sugimori, K. Shirato, M. Morimoto, et al. Percutaneous Ablation Therapy Guided by Contrast-Enhanced Sonography for Patients with Hepatocellular Carcinoma Am. J. Roentgenol., January 1, 2003; 180(1): 143 - 149. [Abstract] [Full Text] [PDF]

				T.-M. Chen, S.-N. Lu, J.-H. Wang, C.-H. Hung, and H.-D. Tung Relationship Between Flash Echo Gray Scale Imaging Features and Pathologic Findings in Hepatic Adenoma J. Ultrasound Med., July 1, 2002; 21(7): 821 - 824. [Full Text] [PDF]

				H. Ding, M. Kudo, H. Onda, Y. Suetomi, Y. Minami, H. Chung, T. Kawasaki, and K. Maekawa Evaluation of Posttreatment Response of Hepatocellular Carcinoma with Contrast-enhanced Coded Phase-Inversion Harmonic US: Comparison with Dynamic CT Radiology, December 1, 2001; 221(3): 721 - 730. [Abstract] [Full Text] [PDF]