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Use of ^99mTc (V) DMSA Scintigraphy in the Detection and Localization of Intestinal Inflammation: Comparison of Findings at Colonoscopy and Biopsy¹

¹ From the Department of Nuclear Medicine (B.F.L., N.T.C.) and Institute of Public Health (S.T.W.), National Cheng Kung University Hospital, 138 Sheng-Li Rd, Tainan 704, Taiwan; and the Departments of Internal Medicine (D.C.W.), Pathology (K.B.T.), and Radiology (G.C.L.) and Institute of Medicine (H.S.Y.), Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Received July 24, 2000; revision requested September 19; final revision received February 21, 2001; accepted February 26. Supported by grant NSC 89-2314-B037-099-M08 from the Taiwan National Science Council. Address correspondence to N.T.C. (e-mail: ntchiu@mail.ncku.edu.tw).

PURPOSE: To evaluate the potential use of technetium 99m (^99mTc) (V) dimercaptosuccinic acid (DMSA) scintigraphy in the detection and localization of intestinal inflammation.

MATERIALS AND METHODS: In a prospective study, 62 patients who were suspected of having intestinal inflammation and 30 control subjects were enrolled. All patients underwent ^99mTc (V) DMSA scintigraphy and colonoscopy with biopsy within 1 week. ^99mTc (V) DMSA scintigrams were interpreted blindly with respect to clinical information, and radiotracer uptake in the bowel segments was graded. The findings were then compared with the results of the colonoscopy and colonoscopic biopsy.

RESULTS: In the detection of intestinal inflammation, findings at ^99mTc (V) DMSA scintigraphy were as follows: true-positive in 55, false-positive in two, true-negative in 32, and false-negative in three. Overall sensitivity was 95%; overall specificity, 94%; and overall accuracy, 95%.

CONCLUSION: Our results show that ^99mTc (V) DMSA scintigraphy is a useful noninvasive diagnostic test for the detection and localization of intestinal inflammation.

Index terms: Colonoscopy • Enteritis, 75.26 • Inflammation, radionuclide studies, 75.26, 75.1217 • Intestines, biopsy, 75.126 • Intestines, radionuclide studies, 75.1217

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