HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lim, J. H. Articles by Kim, Y. I. Search for Related Content PubMed PubMed Citation Articles by Lim, J. H. Articles by Kim, Y. I.

Conspicuity of Hepatocellular Nodular Lesions in Cirrhotic Livers at Ferumoxides-enhanced MR Imaging: Importance of Kupffer Cell Number¹

¹ From the Departments of Radiology (J.H.L., D.C., S.K.C., S.H.K., W.J.L., H.K.L.), Diagnostic Pathology (C.K.P.), Gastroenterology (S.W.P.), and General Surgery (Y.I.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea. Received November 8, 2000; revision requested January 9, 2001; revision received February 14; accepted March 19. Address correspondence to C.K.P. (e-mail: ckpark@smc.samsung.co.kr)

PURPOSE: To correlate the conspicuity of hepatocellular carcinomas and dysplastic nodules on ferumoxides-enhanced magnetic resonance (MR) images with the number of Kupffer cells in the hepatic lesions, as compared with that in background liver in histopathologic findings.

MATERIALS AND METHODS: Sixty-nine histopathologically proved moderately or poorly differentiated hepatocellular carcinomas, 10 well-differentiated hepatocellular carcinomas, and 19 dysplastic nodules were retrospectively studied in 68 patients with cirrhosis who underwent ferumoxides-enhanced MR imaging. The contrast-to-noise ratio between the nodules and surrounding parenchyma was calculated at T2-weighted fast spin-echo imaging, and the difference in the number of Kupffer cells between the nodules and surrounding hepatic tissue was calculated histopathologically. The results of MR imaging and histopathologic examination were correlated.

RESULTS: All 69 moderately or poorly differentiated hepatocellular carcinomas had high contrast-to-noise ratios at MR imaging and large differences in the number of Kupffer cells. Six of the 10 well-differentiated hepatocellular carcinomas had contrast-to-noise ratios of zero or nearly zero, and five of these had little difference in the number of Kupffer cells. All 19 dysplastic nodules had contrast-to-noise ratios of zero or nearly zero, and there were virtually no differences in the number of Kupffer cells.

CONCLUSION: Hepatocellular nodule conspicuity at ferumoxides-enhanced MR imaging depends on differences in the number of Kupffer cells within a nodule and the surrounding cirrhotic liver; moderately or poorly differentiated hepatocellular carcinomas can be distinguished from well-differentiated hepatocellular carcinomas and dysplastic nodules.

Index terms: Iron • Liver, diseases, 761.323, 761.794 • Liver, MR, 761.121411, 761.121412, 761.121415, 761.12143 • Liver, nodules, 761.319 • Magnetic resonance (MR), contrast enhancement 761.12143

This article has been cited by other articles:

				R. F. Hanna, D. A. Aguirre, N. Kased, S. C. Emery, M. R. Peterson, and C. B. Sirlin Cirrhosis-associated Hepatocellular Nodules: Correlation of Histopathologic and MR Imaging Features RadioGraphics, May 1, 2008; 28(3): 747 - 769. [Abstract] [Full Text] [PDF]

				R. F. Hanna, N. Kased, S. W. Kwan, A. C. Gamst, A. C. Santosa, T. Hassanein, and C. B. Sirlin Double-Contrast MRI for Accurate Staging of Hepatocellular Carcinoma in Patients with Cirrhosis Am. J. Roentgenol., January 1, 2008; 190(1): 47 - 57. [Abstract] [Full Text] [PDF]

				D. Choi, H. K. Lim, J.-W. Joh, S.-J. Kim, M. J. Kim, H. Rhim, Y.-s. Kim, B. C. Yoo, S. W. Paik, and C. K. Park Combined Hepatectomy and Radiofrequency Ablation for Multifocal Hepatocellular Carcinomas: Long-term Follow-up Results and Prognostic Factors Ann. Surg. Oncol., December 1, 2007; 14(12): 3510 - 3518. [Abstract] [Full Text] [PDF]

				Y. H. Lee, S. H. Kim, M.-Y. Cho, K. Y. Shim, and M. S. Kim Focal Nodular Hyperplasia-Like Nodules in Alcoholic Liver Cirrhosis: Radiologic-Pathologic Correlation Am. J. Roentgenol., May 1, 2007; 188(5): W459 - W463. [Abstract] [Full Text] [PDF]

				M.-J. Kim, J. H. Kim, J. Y. Choi, S. H. Park, J.-J. Chung, K. W. Kim, and D. G. Mitchell Optimal TE for SPIO-enhanced gradient-recalled echo MRI for the detection of focal hepatic lesions. Am. J. Roentgenol., September 1, 2006; 187(3): W255 - W266. [Abstract] [Full Text] [PDF]

				C-S Li, R-C Chen, H-Y Tu, L-S Shih, T-A Zhang, J-M Lii, W-T Chen, S-J Duh, and L-C Chiang Imaging well-differentiated hepatocellular carcinoma with dynamic triple-phase helical computed tomography Br. J. Radiol., August 1, 2006; 79(944): 659 - 665. [Abstract] [Full Text] [PDF]

				M. E. J. Pijl, J. Doornbos, M. N. J. M. Wasser, H. C. van Houwelingen, R. A. E. M. Tollenaar, and J. L. Bloem Quantitative Analysis of Focal Masses at MR Imaging: A Plea for Standardization Radiology, June 1, 2004; 231(3): 737 - 744. [Abstract] [Full Text] [PDF]

				B. K. Kang, J. H. Lim, S. H. Kim, D. Choi, H. K. Lim, W. J. Lee, and S. J. Lee Preoperative Depiction of Hepatocellular Carcinoma: Ferumoxides-enhanced MR Imaging versus Triple-Phase Helical CT Radiology, January 1, 2003; 226(1): 79 - 85. [Abstract] [Full Text] [PDF]

				S. K. Kim, S. H. Kim, W. J. Lee, H. Kim, J. W. Seo, D. Choi, H. K. Lim, S. J. Lee, and J. H. Lim Preoperative Detection of Hepatocellular Carcinoma: Ferumoxides-Enhanced Versus Mangafodipir Trisodium--Enhanced MR Imaging Am. J. Roentgenol., September 1, 2002; 179(3): 741 - 750. [Abstract] [Full Text] [PDF]