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DOI: 10.1148/radiol.2203001662
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(Radiology. 2001;220:822-826.)
© RSNA, 2001

Technical Developments

Human Knee: In Vivo T1{rho}-weighted MR Imaging at 1.5 T—Preliminary Experience1

Umamaheswar Duvvuri, MS, Sridhar R. Charagundla, MD, PhD, Sagar B. Kudchodkar, MS, Jonathan H. Kaufman, PhD, J. Bruce Kneeland, MD, Rahim Rizi, PhD, John S. Leigh, PhD and Ravinder Reddy, PhD

1 From the Department of Radiology, University of Pennsylvania Medical Center, Philadelphia. Received October 16, 2000; revision requested November 26; revision received February 15, 2001; accepted March 9. Supported by grants AR45242 and AR45404 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Institutes of Health. Address correspondence to U.D., B-1 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6100 (e-mail: uduvvuri@mail.med.upenn.edu).

A fast spin-echo sequence weighted with a time constant that defines the magnetic relaxation of spins under the influence of a radio-frequency field (T1{rho}) was used in six subjects to measure magnetic resonance (MR) relaxation times in the knee joint with a 1.5-T MR imager. A quantitative comparison of T2- and T1{rho}-weighted MR images was also performed. Substantial T1{rho} dispersion was demonstrated in human articular cartilage, but muscle did not demonstrate much dispersion. T1{rho}-weighted images depicted a chondral lesion with 25% better signal-difference-to-noise ratios than comparable T2-weighted images. This technique may depict cartilage and muscular abnormalities.

Index terms: Cartilage, 4521.121411, 4521.121415 • Cartilage, MR, 4521.121411, 4521.121415 • Knee, arthritis, 452.77 • Knee, MR, 452.121411, 452.121415, 452.121416 • Muscles, MR, 459.121411, 459.121415




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