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Human Knee: In Vivo T1-weighted MR Imaging at 1.5 T—Preliminary Experience¹

¹ From the Department of Radiology, University of Pennsylvania Medical Center, Philadelphia. Received October 16, 2000; revision requested November 26; revision received February 15, 2001; accepted March 9. Supported by grants AR45242 and AR45404 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Institutes of Health. Address correspondence to U.D., B-1 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6100 (e-mail: uduvvuri@mail.med.upenn.edu).

A fast spin-echo sequence weighted with a time constant that defines the magnetic relaxation of spins under the influence of a radio-frequency field (T1) was used in six subjects to measure magnetic resonance (MR) relaxation times in the knee joint with a 1.5-T MR imager. A quantitative comparison of T2- and T1-weighted MR images was also performed. Substantial T1 dispersion was demonstrated in human articular cartilage, but muscle did not demonstrate much dispersion. T1-weighted images depicted a chondral lesion with 25% better signal-difference-to-noise ratios than comparable T2-weighted images. This technique may depict cartilage and muscular abnormalities.

Index terms: Cartilage, 4521.121411, 4521.121415 • Cartilage, MR, 4521.121411, 4521.121415 • Knee, arthritis, 452.77 • Knee, MR, 452.121411, 452.121415, 452.121416 • Muscles, MR, 459.121411, 459.121415

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