HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Möhlenkamp, S. Articles by Ritman, E. L. Search for Related Content PubMed PubMed Citation Articles by Möhlenkamp, S. Articles by Ritman, E. L.

Coronary Microvascular Functional Reserve: Quantification of Long-term Changes with Electron-Beam CT—Preliminary Results in a Porcine Model¹

¹ From the Departments of Physiology and Biophysics (S.M., E.L.R.), the Department of Internal Medicine, Divisions of Cardiovascular Diseases (T.R.B., A.L.) and Hypertension (L.O.L.), the Section of Biostatistics (A.L.W., V.S.P.), and the Department of Diagnostic Radiology (P.F.S.), Mayo Clinic and Foundation, 200 First St SW, Alfred 2-409, Rochester, MN 55905. Received May 25, 2000; revision requested July 12; final revision received March 5, 2001; accepted March 23. Supported in part by National Institutes of Health research grant HL-43025. Address correspondence to E.L.R. (e-mail: elran@mayo.edu).

PURPOSE: To evaluate the ability of electron-beam computed tomography (CT) to help quantify long-term changes in coronary microvascular functional reserve in a porcine model.

MATERIALS AND METHODS: Electron-beam CT–based intramyocardial blood volume and perfusion and Doppler ultrasonography (US)–based intracoronary blood flow were obtained in 13 pigs at baseline and again 3 months later. Measurements were obtained at rest and after the administration of adenosine. The short-term variation during 30 minutes of electron-beam CT measurements was assessed in nine additional pigs.

RESULTS: Short-term variation of blood volume and perfusion averaged 8% and 9%, respectively, and was similar for both weight groups at rest and after adenosine administration. At rest, intracoronary blood flow, blood volume, and perfusion remained unchanged from baseline to follow-up. Long-term increases (percentage change with adenosine relative to that at rest) in blood volume and perfusion reserves were consistent with increasing intracoronary blood flow reserves. Despite these long-term changes in intracoronary blood flow, blood volume, and perfusion, the blood volume–to-perfusion relationship suggests a similar blood volume distribution among different microvascular functional components in normal porcine myocardium at both weight groups.

CONCLUSION: Electron-beam CT may be of value for quantifying long-term changes in intramyocardial microvascular function.

Index terms: Blood, volume • Computed tomography (CT), electron beam, 51.12119 • Coronary vessels, CT, 54.12119 • Coronary vessels, flow dynamics, 54.12119 • Myocardium, 511.12119

This article has been cited by other articles:

				R. T. George, C. Silva, M. A.S. Cordeiro, A. DiPaula, D. R. Thompson, W. F. McCarthy, T. Ichihara, J. A.C. Lima, and A. C. Lardo Multidetector Computed Tomography Myocardial Perfusion Imaging During Adenosine Stress J. Am. Coll. Cardiol., July 4, 2006; 48(1): 153 - 160. [Abstract] [Full Text] [PDF]

				U. J. Schoepf, C. R. Becker, B. M. Ohnesorge, and E. K. Yucel CT of Coronary Artery Disease Radiology, July 1, 2004; 232(1): 18 - 37. [Abstract] [Full Text] [PDF]

				X.-Y. Zhu, M. Rodriguez-Porcel, M. D. Bentley, A. R. Chade, V. Sica, C. Napoli, N. Caplice, E. L. Ritman, A. Lerman, and L. O. Lerman Antioxidant Intervention Attenuates Myocardial Neovascularization in Hypercholesterolemia Circulation, May 4, 2004; 109(17): 2109 - 2115. [Abstract] [Full Text] [PDF]

				M. Rodriguez-Porcel, J. Herrman, A. R. Chade, J. D. Krier, J. F. Breen, A. Lerman, and L. O. Lerman Long-Term Antioxidant Intervention Improves Myocardial Microvascular Function in Experimental Hypertension Hypertension, February 1, 2004; 43(2): 493 - 498. [Abstract] [Full Text] [PDF]

				M. Rodriguez-Porcel, A. Lerman, J. Herrmann, R. S. Schwartz, T. Sawamura, M. Condorelli, C. Napoli, and L. O. Lerman Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature Cardiovasc Res, April 1, 2003; 58(1): 213 - 221. [Abstract] [Full Text] [PDF]

				S. Mohlenkamp, P. E Beighley, E. A Pfeifer, T. R Behrenbeck, P. F Sheedy II, and E. L Ritman Intramyocardial blood volume, perfusion and transit time in response to embolization of different sized microvessels Cardiovasc Res, March 1, 2003; 57(3): 843 - 852. [Abstract] [Full Text] [PDF]

				S. MOHLENKAMP, L. O. LERMAN, Z. BAJZER, P. E. LUND, and E. L. RITMAN Quantification of Myocardial Microcirculatory Function with X-ray CT Ann. N.Y. Acad. Sci., October 1, 2002; 972(1): 307 - 316. [Abstract] [Full Text] [PDF]

				A. D. RULE, Z. BAJZER, E. L. RITMAN, and L. O. LERMAN Renal Handling of X-ray Contrast Media Imaging and Exploration with Electron Beam CT Ann. N.Y. Acad. Sci., October 1, 2002; 972(1): 317 - 324. [Abstract] [Full Text] [PDF]

				P. O. Bonetti, S. H. Wilson, M. Rodriguez-Porcel, D. R. Holmes Jr, L. O. Lerman, and A. Lerman Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering J. Am. Coll. Cardiol., August 7, 2002; 40(3): 546 - 554. [Abstract] [Full Text] [PDF]